Abstract
Nuclear factor ΚB (NF-ΚB) is a family of inducible transcription factors that plays a vital role in different aspects of immune responses. NF-ΚB is normally sequestered in the cytoplasm as inactive complexes via physical association with inhibitory proteins termed IΚBs. In response to immune and stress stimuli, NF-ΚB members become activated via two major signaling pathways, the canonical and noncanonical pathways, and move to the nucleus to exert transcriptional functions. NF-ΚB is vital for normal immune responses against infections, but deregulated NF-ΚB activation is a major cause of inflammatory diseases. Accumulated studies suggest the involvement of NF-ΚB in the pathogenesis of renal inflammation caused by infection, injury, or autoimmune factors. In this review, we discuss the current understanding regarding the activation and function of NF-ΚB in different types of kidney diseases.
Original language | English (US) |
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Article number | 63 |
Journal | Cell and Bioscience |
Volume | 5 |
Issue number | 1 |
DOIs | |
State | Published - Nov 16 2015 |
Keywords
- IgA nephropathy
- Inflammation
- NF-ΚB
- Nephritis
- Renal diseases
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology