Abstract
The CCAAT-binding factor CBF/NF-Y is needed for cell proliferation and early embryonic development. NF-Y can regulate the expression of different cell type-specific genes that are activated by various physiological signaling pathways. Dysregulation of NF-Y was observed in pathogenic conditions in humans such as scleroderma, neurodegenerative disease, and cancer. Conditional inactivation of the NF-YA gene in mice demonstrated that NF-Y activity is essential for normal tissue homeostasis, survival, and metabolic function. Altogether, NF-Y is an essential transcription factor that plays a critical role in mammalian development, from the early stages to adulthood, and in human pathogenesis. This article is part of a Special Issue entitled: Nuclear Factor Y in Development and Disease, edited by Prof. Roberto Mantovani.
Original language | English (US) |
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Pages (from-to) | 598-603 |
Number of pages | 6 |
Journal | Biochimica et Biophysica Acta - Gene Regulatory Mechanisms |
Volume | 1860 |
Issue number | 5 |
DOIs | |
State | Published - May 1 2017 |
Keywords
- CCAAT binding factor
- Cell type specific
- Conditional inactivation in mice
- NF-Y
- Tissue homeostasis
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics