Non-coding RNAs as regulators of mammary development and breast cancer

Hai Long Piao; Li Ma

doi:10.1007/s10911-012-9245-5

Non-coding RNAs as regulators of mammary development and breast cancer

Hai Long Piao, Li Ma

Experimental Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Abstract

Over the past decade, non-coding RNAs (ncRNAs) have become a new paradigm of gene regulation. ncRNAs are classified into two major groups based on their size: long non-coding RNAs (lncRNAs) and small non-coding RNAs (including microRNAs, piRNAs, snoRNAs, and endogenous siRNAs). Here we review the recently emerging role of ncRNAs in mammary development, tumorigenesis, and metastasis, with the focus being on microRNAs (miRNAs) and lncRNAs. These findings shed new light on normal development and malignant progression, and suggest the potential for using ncRNAs as new biomarkers of breast cancer and targets for treatment.

Original language	English (US)
Pages (from-to)	33-42
Number of pages	10
Journal	Journal of Mammary Gland Biology and Neoplasia
Volume	17
Issue number	1
DOIs	https://doi.org/10.1007/s10911-012-9245-5
State	Published - Mar 2012

Keywords

Breast cancer
Epithelial-mesenchymal transition
Long non-coding RNA
Mammary development
Metastasis
MicroRNA

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/s10911-012-9245-5

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title = "Non-coding RNAs as regulators of mammary development and breast cancer",

abstract = "Over the past decade, non-coding RNAs (ncRNAs) have become a new paradigm of gene regulation. ncRNAs are classified into two major groups based on their size: long non-coding RNAs (lncRNAs) and small non-coding RNAs (including microRNAs, piRNAs, snoRNAs, and endogenous siRNAs). Here we review the recently emerging role of ncRNAs in mammary development, tumorigenesis, and metastasis, with the focus being on microRNAs (miRNAs) and lncRNAs. These findings shed new light on normal development and malignant progression, and suggest the potential for using ncRNAs as new biomarkers of breast cancer and targets for treatment.",

keywords = "Breast cancer, Epithelial-mesenchymal transition, Long non-coding RNA, Mammary development, Metastasis, MicroRNA",

author = "Piao, {Hai Long} and Li Ma",

note = "Funding Information: Acknowledgements The ncRNA research in the Ma Lab is supported by an NIH Pathway to Independence (K99/R00) Award CA138572, a CPRIT First-Time, Tenure-Track Faculty Award R1004, a University of Texas STARS Award, and a Faculty Development Award from MD Anderson{\textquoteright}s Cancer Center Support Grant CA016672 from NIH.",

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doi = "10.1007/s10911-012-9245-5",

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AU - Ma, Li

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PY - 2012/3

Y1 - 2012/3

N2 - Over the past decade, non-coding RNAs (ncRNAs) have become a new paradigm of gene regulation. ncRNAs are classified into two major groups based on their size: long non-coding RNAs (lncRNAs) and small non-coding RNAs (including microRNAs, piRNAs, snoRNAs, and endogenous siRNAs). Here we review the recently emerging role of ncRNAs in mammary development, tumorigenesis, and metastasis, with the focus being on microRNAs (miRNAs) and lncRNAs. These findings shed new light on normal development and malignant progression, and suggest the potential for using ncRNAs as new biomarkers of breast cancer and targets for treatment.

AB - Over the past decade, non-coding RNAs (ncRNAs) have become a new paradigm of gene regulation. ncRNAs are classified into two major groups based on their size: long non-coding RNAs (lncRNAs) and small non-coding RNAs (including microRNAs, piRNAs, snoRNAs, and endogenous siRNAs). Here we review the recently emerging role of ncRNAs in mammary development, tumorigenesis, and metastasis, with the focus being on microRNAs (miRNAs) and lncRNAs. These findings shed new light on normal development and malignant progression, and suggest the potential for using ncRNAs as new biomarkers of breast cancer and targets for treatment.

KW - Breast cancer

KW - Epithelial-mesenchymal transition

KW - Long non-coding RNA

KW - Mammary development

KW - Metastasis

KW - MicroRNA

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Non-coding RNAs as regulators of mammary development and breast cancer

Abstract

Keywords

ASJC Scopus subject areas

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