TY - JOUR
T1 - Non-Coding RNAs
T2 - Foes or Friends for Targeting Tumor Microenvironment
AU - Szymanowska, Anna
AU - Rodriguez-Aguayo, Cristian
AU - Lopez-Berestein, Gabriel
AU - Amero, Paola
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/10
Y1 - 2023/10
N2 - Non-coding RNAs (ncRNAs) are a group of molecules critical for cell development and growth regulation. They are key regulators of important cellular pathways in the tumor microenvironment. To analyze ncRNAs in the tumor microenvironment, the use of RNA sequencing technology has revolutionized the field. The advancement of this technique has broadened our understanding of the molecular biology of cancer, presenting abundant possibilities for the exploration of novel biomarkers for cancer treatment. In this review, we will summarize recent achievements in understanding the complex role of ncRNA in the tumor microenvironment, we will report the latest studies on the tumor microenvironment using RNA sequencing, and we will discuss the potential use of ncRNAs as therapeutics for the treatment of cancer.
AB - Non-coding RNAs (ncRNAs) are a group of molecules critical for cell development and growth regulation. They are key regulators of important cellular pathways in the tumor microenvironment. To analyze ncRNAs in the tumor microenvironment, the use of RNA sequencing technology has revolutionized the field. The advancement of this technique has broadened our understanding of the molecular biology of cancer, presenting abundant possibilities for the exploration of novel biomarkers for cancer treatment. In this review, we will summarize recent achievements in understanding the complex role of ncRNA in the tumor microenvironment, we will report the latest studies on the tumor microenvironment using RNA sequencing, and we will discuss the potential use of ncRNAs as therapeutics for the treatment of cancer.
KW - anticancer therapy
KW - cancer
KW - immune response
KW - non-coding RNAs
KW - tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85175373455&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85175373455&partnerID=8YFLogxK
U2 - 10.3390/ncrna9050052
DO - 10.3390/ncrna9050052
M3 - Review article
C2 - 37736898
AN - SCOPUS:85175373455
SN - 2311-553X
VL - 9
JO - Non-coding RNA
JF - Non-coding RNA
IS - 5
M1 - 52
ER -