TY - JOUR
T1 - Non-coding RNAs in disease
T2 - from mechanisms to therapeutics
AU - Nemeth, Kinga
AU - Bayraktar, Recep
AU - Ferracin, Manuela
AU - Calin, George A.
N1 - Publisher Copyright:
© Springer Nature Limited 2023.
PY - 2024/3
Y1 - 2024/3
N2 - Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are not translated into proteins. Since their discovery, ncRNAs have emerged as important regulators of multiple biological functions across a range of cell types and tissues, and their dysregulation has been implicated in disease. Notably, much research has focused on the link between microRNAs (miRNAs) and human cancers, although other ncRNAs, such as long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are also emerging as relevant contributors to human disease. In this Review, we summarize our current understanding of the roles of miRNAs, lncRNAs and circRNAs in cancer and other major human diseases, notably cardiovascular, neurological and infectious diseases. Further, we discuss the potential use of ncRNAs as biomarkers of disease and as therapeutic targets.
AB - Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are not translated into proteins. Since their discovery, ncRNAs have emerged as important regulators of multiple biological functions across a range of cell types and tissues, and their dysregulation has been implicated in disease. Notably, much research has focused on the link between microRNAs (miRNAs) and human cancers, although other ncRNAs, such as long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are also emerging as relevant contributors to human disease. In this Review, we summarize our current understanding of the roles of miRNAs, lncRNAs and circRNAs in cancer and other major human diseases, notably cardiovascular, neurological and infectious diseases. Further, we discuss the potential use of ncRNAs as biomarkers of disease and as therapeutic targets.
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U2 - 10.1038/s41576-023-00662-1
DO - 10.1038/s41576-023-00662-1
M3 - Review article
C2 - 37968332
AN - SCOPUS:85176808150
SN - 1471-0056
VL - 25
SP - 211
EP - 232
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 3
ER -