Non-coding RNAs in IGF-1R signaling regulation: The underlying pathophysiological link between diabetes and cancer

Baoqing Chen; Junyan Li; Dongmei Chi; Iman Sahnoune; Steliana Calin; Leonard Girnita; George A. Calin

doi:10.3390/cells8121638

Non-coding RNAs in IGF-1R signaling regulation: The underlying pathophysiological link between diabetes and cancer

Baoqing Chen, Junyan Li, Dongmei Chi, Iman Sahnoune, Steliana Calin, Leonard Girnita, George A. Calin

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

The intricate molecular network shared between diabetes mellitus (DM) and cancer has been broadly understood. DM has been associated with several hormone-dependent malignancies, including breast, pancreatic, and colorectal cancer (CRC). Insulin resistance, hyperglycemia, and inflammation are the main pathophysiological mechanisms linking DM to cancer. Non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are widely appreciated as pervasive regulators of gene expression, governing the evolution of metabolic disorders, including DM and cancer. The ways ncRNAs affect the development of DM complicated with cancer have only started to be revealed in recent years. Insulin-like growth factor 1 receptor (IGF-1R) signaling is a master regulator of pathophysiological processes directing DM and cancer. In this review, we briefly summarize a number of well-known miRNAs and lncRNAs that regulate the IGF-1R in DM and cancer, respectively, and further discuss the potential underlying molecular pathogenesis of this disease association.

Original language	English (US)
Article number	1638
Journal	Cells
Volume	8
Issue number	12
DOIs	https://doi.org/10.3390/cells8121638
State	Published - Dec 2019

Keywords

Cancer
Diabetes
IGF-1R
LncRNAs
MicoRNAs

ASJC Scopus subject areas

General Medicine

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10.3390/cells8121638

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title = "Non-coding RNAs in IGF-1R signaling regulation: The underlying pathophysiological link between diabetes and cancer",

abstract = "The intricate molecular network shared between diabetes mellitus (DM) and cancer has been broadly understood. DM has been associated with several hormone-dependent malignancies, including breast, pancreatic, and colorectal cancer (CRC). Insulin resistance, hyperglycemia, and inflammation are the main pathophysiological mechanisms linking DM to cancer. Non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are widely appreciated as pervasive regulators of gene expression, governing the evolution of metabolic disorders, including DM and cancer. The ways ncRNAs affect the development of DM complicated with cancer have only started to be revealed in recent years. Insulin-like growth factor 1 receptor (IGF-1R) signaling is a master regulator of pathophysiological processes directing DM and cancer. In this review, we briefly summarize a number of well-known miRNAs and lncRNAs that regulate the IGF-1R in DM and cancer, respectively, and further discuss the potential underlying molecular pathogenesis of this disease association.",

keywords = "Cancer, Diabetes, IGF-1R, LncRNAs, MicoRNAs",

author = "Baoqing Chen and Junyan Li and Dongmei Chi and Iman Sahnoune and Steliana Calin and Leonard Girnita and Calin, {George A.}",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2019",

month = dec,

doi = "10.3390/cells8121638",

language = "English (US)",

volume = "8",

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T1 - Non-coding RNAs in IGF-1R signaling regulation

T2 - The underlying pathophysiological link between diabetes and cancer

AU - Chen, Baoqing

AU - Li, Junyan

AU - Chi, Dongmei

AU - Sahnoune, Iman

AU - Calin, Steliana

AU - Girnita, Leonard

AU - Calin, George A.

PY - 2019/12

Y1 - 2019/12

N2 - The intricate molecular network shared between diabetes mellitus (DM) and cancer has been broadly understood. DM has been associated with several hormone-dependent malignancies, including breast, pancreatic, and colorectal cancer (CRC). Insulin resistance, hyperglycemia, and inflammation are the main pathophysiological mechanisms linking DM to cancer. Non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are widely appreciated as pervasive regulators of gene expression, governing the evolution of metabolic disorders, including DM and cancer. The ways ncRNAs affect the development of DM complicated with cancer have only started to be revealed in recent years. Insulin-like growth factor 1 receptor (IGF-1R) signaling is a master regulator of pathophysiological processes directing DM and cancer. In this review, we briefly summarize a number of well-known miRNAs and lncRNAs that regulate the IGF-1R in DM and cancer, respectively, and further discuss the potential underlying molecular pathogenesis of this disease association.

AB - The intricate molecular network shared between diabetes mellitus (DM) and cancer has been broadly understood. DM has been associated with several hormone-dependent malignancies, including breast, pancreatic, and colorectal cancer (CRC). Insulin resistance, hyperglycemia, and inflammation are the main pathophysiological mechanisms linking DM to cancer. Non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are widely appreciated as pervasive regulators of gene expression, governing the evolution of metabolic disorders, including DM and cancer. The ways ncRNAs affect the development of DM complicated with cancer have only started to be revealed in recent years. Insulin-like growth factor 1 receptor (IGF-1R) signaling is a master regulator of pathophysiological processes directing DM and cancer. In this review, we briefly summarize a number of well-known miRNAs and lncRNAs that regulate the IGF-1R in DM and cancer, respectively, and further discuss the potential underlying molecular pathogenesis of this disease association.

KW - Cancer

KW - Diabetes

KW - IGF-1R

KW - LncRNAs

KW - MicoRNAs

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DO - 10.3390/cells8121638

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Non-coding RNAs in IGF-1R signaling regulation: The underlying pathophysiological link between diabetes and cancer

Abstract

Keywords

ASJC Scopus subject areas

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