Non-random primary and secondary chromosomal abnormalities in human gastric cancers

Maneesha Yadav; Vicki L. Hopwood; Asha S. Multani; Paul F. Mansfield; Yutaka Takahashi; Bradley W. Mcintyre; Taturo Udagawa; Sen Pathak

Non-random primary and secondary chromosomal abnormalities in human gastric cancers

Maneesha Yadav, Vicki L. Hopwood, Asha S. Multani, Paul F. Mansfield, Yutaka Takahashi, Bradley W. Mcintyre, Taturo Udagawa, Sen Pathak

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

By using Giemsa-banding and fluorescence in situ hybridization techniques, we have been able to identify primary and secondary cytogenetic abnormalities in four gastric tumors at different stages of development. Structural and numerical abnormalities were present in all four gastric tumors in chromosomes 3, 7, 11, and X. Other abnormalities involving chromosomes 1, 5, 6, 8, 13, 15, 17, 18, 19 and 22 were observed, but only in three advanced gastric tumors, suggesting that these were secondary/tertiary genetic defects. Based on these results it was possible for us to decipher primary and secondary genetic abnormalities in these four gastric tumors.

Original language	English (US)
Pages (from-to)	1787-1795
Number of pages	9
Journal	Anticancer research
Volume	16
Issue number	4 A
State	Published - Jul 1996

Keywords

Cytogenetics
Fluorescence in situ hybridization (FISH)
Gastric cancer
Histopathology
Karyotype

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Non-random primary and secondary chromosomal abnormalities in human gastric cancers",

abstract = "By using Giemsa-banding and fluorescence in situ hybridization techniques, we have been able to identify primary and secondary cytogenetic abnormalities in four gastric tumors at different stages of development. Structural and numerical abnormalities were present in all four gastric tumors in chromosomes 3, 7, 11, and X. Other abnormalities involving chromosomes 1, 5, 6, 8, 13, 15, 17, 18, 19 and 22 were observed, but only in three advanced gastric tumors, suggesting that these were secondary/tertiary genetic defects. Based on these results it was possible for us to decipher primary and secondary genetic abnormalities in these four gastric tumors.",

keywords = "Cytogenetics, Fluorescence in situ hybridization (FISH), Gastric cancer, Histopathology, Karyotype",

author = "Maneesha Yadav and Hopwood, {Vicki L.} and Multani, {Asha S.} and Mansfield, {Paul F.} and Yutaka Takahashi and Mcintyre, {Bradley W.} and Taturo Udagawa and Sen Pathak",

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T1 - Non-random primary and secondary chromosomal abnormalities in human gastric cancers

AU - Yadav, Maneesha

AU - Hopwood, Vicki L.

AU - Multani, Asha S.

AU - Mansfield, Paul F.

AU - Takahashi, Yutaka

AU - Mcintyre, Bradley W.

AU - Udagawa, Taturo

AU - Pathak, Sen

PY - 1996/7

Y1 - 1996/7

N2 - By using Giemsa-banding and fluorescence in situ hybridization techniques, we have been able to identify primary and secondary cytogenetic abnormalities in four gastric tumors at different stages of development. Structural and numerical abnormalities were present in all four gastric tumors in chromosomes 3, 7, 11, and X. Other abnormalities involving chromosomes 1, 5, 6, 8, 13, 15, 17, 18, 19 and 22 were observed, but only in three advanced gastric tumors, suggesting that these were secondary/tertiary genetic defects. Based on these results it was possible for us to decipher primary and secondary genetic abnormalities in these four gastric tumors.

AB - By using Giemsa-banding and fluorescence in situ hybridization techniques, we have been able to identify primary and secondary cytogenetic abnormalities in four gastric tumors at different stages of development. Structural and numerical abnormalities were present in all four gastric tumors in chromosomes 3, 7, 11, and X. Other abnormalities involving chromosomes 1, 5, 6, 8, 13, 15, 17, 18, 19 and 22 were observed, but only in three advanced gastric tumors, suggesting that these were secondary/tertiary genetic defects. Based on these results it was possible for us to decipher primary and secondary genetic abnormalities in these four gastric tumors.

KW - Cytogenetics

KW - Fluorescence in situ hybridization (FISH)

KW - Gastric cancer

KW - Histopathology

KW - Karyotype

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Non-random primary and secondary chromosomal abnormalities in human gastric cancers

Abstract

Keywords

ASJC Scopus subject areas

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