Non-Small Cell Carcinoma

Donald R. Lazarus; Chad D. Strange; Jitesh Ahuja; Girish S. Shroff; Bradley S. Sabloff; Patricia M. de Groot; Mylene T. Truong; Cesar A. Moran

doi:10.1007/978-3-031-21040-2_10

Non-Small Cell Carcinoma

Donald R. Lazarus, Chad D. Strange, Jitesh Ahuja, Girish S. Shroff, Bradley S. Sabloff, Patricia M. de Groot, Mylene T. Truong, Cesar A. Moran

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Lung cancer is the leading cause of cancer death in the world, with over two million new cases and over 1.7 million deaths reported in 2018. In the United States alone lung cancer is responsible for more deaths than colon, breast, and prostate cancer combined. Most patients with lung cancer present with advanced disease, and prognosis is poor. Non-small cell lung carcinomas (NSCLC) account for approximately 80% of primary lung cancers. Tobacco use is responsible for 85–90% of cases of lung cancer in countries where smoking is common. Cough is the most common symptom present in patients with lung cancer, occurring in 45–75% of patients. Other common presenting symptoms include weight loss, dyspnea, hemoptysis, and chest pain. NSCLC is staged using the tumor-node-metastasis (TNM) classification system as developed by the International Association for the Study of Lung Cancer, which has undergone periodic revisions based on metadata. The use of immunohistochemical studies and molecular analysis plays an important role in the diagnosis and treatment alternatives.

Original language	English (US)
Title of host publication	The Thorax
Subtitle of host publication	Medical, Radiological, and Pathological Assessment
Publisher	Springer International Publishing
Pages	311-372
Number of pages	62
ISBN (Electronic)	9783031210402
ISBN (Print)	9783031210396
DOIs	https://doi.org/10.1007/978-3-031-21040-2_10
State	Published - Jan 1 2023

Keywords

Lung adenocarcinoma
Lung cancer
Metastasis
Node
Squamous cell lung cancer
TNM staging
Tumor

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-3-031-21040-2_10

Cite this

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title = "Non-Small Cell Carcinoma",

abstract = "Lung cancer is the leading cause of cancer death in the world, with over two million new cases and over 1.7 million deaths reported in 2018. In the United States alone lung cancer is responsible for more deaths than colon, breast, and prostate cancer combined. Most patients with lung cancer present with advanced disease, and prognosis is poor. Non-small cell lung carcinomas (NSCLC) account for approximately 80% of primary lung cancers. Tobacco use is responsible for 85–90% of cases of lung cancer in countries where smoking is common. Cough is the most common symptom present in patients with lung cancer, occurring in 45–75% of patients. Other common presenting symptoms include weight loss, dyspnea, hemoptysis, and chest pain. NSCLC is staged using the tumor-node-metastasis (TNM) classification system as developed by the International Association for the Study of Lung Cancer, which has undergone periodic revisions based on metadata. The use of immunohistochemical studies and molecular analysis plays an important role in the diagnosis and treatment alternatives.",

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AU - de Groot, Patricia M.

AU - Truong, Mylene T.

AU - Moran, Cesar A.

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Non-Small Cell Carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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