Non-T, non-B acute lymphoblastic leukemia (L3) with t(8;22) and two 14q+ chromosomes

R. S.K. Chaganti; Suresh C. Jhanwar; Zalmen Arlin; Benjamin Koziner; Appaji Ambati; Michael Andreeff; Bayard D. Clarkson

doi:10.1016/0165-4608(83)90110-3

Non-T, non-B acute lymphoblastic leukemia (L3) with t(8;22) and two 14q+ chromosomes

R. S.K. Chaganti, Suresh C. Jhanwar, Zalmen Arlin, Benjamin Koziner, Appaji Ambati, Michael Andreeff, Bayard D. Clarkson

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A patient with L3 leukemia is reported whose leukemic cells were characterized cytogenetically by a duplication of the long arm segment 1q25→q42, trisomy for chromosome 7, t(8;22)(q24;q11), and two 14q+ chromosomes. Immunologic marker analysis revealed the leukemic cells to be of the non-T, non-B ("null") type. This observation, when considered in conjunction with a previous report of heterogeneity in cell lineages of L3 leukemias, raises the possibility of some lymphoid neoplasms arising in stem cells.

Original language	English (US)
Pages (from-to)	95-103
Number of pages	9
Journal	Cancer Genetics and Cytogenetics
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(83)90110-3
State	Published - Sep 1983
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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abstract = "A patient with L3 leukemia is reported whose leukemic cells were characterized cytogenetically by a duplication of the long arm segment 1q25→q42, trisomy for chromosome 7, t(8;22)(q24;q11), and two 14q+ chromosomes. Immunologic marker analysis revealed the leukemic cells to be of the non-T, non-B ({"}null{"}) type. This observation, when considered in conjunction with a previous report of heterogeneity in cell lineages of L3 leukemias, raises the possibility of some lymphoid neoplasms arising in stem cells.",

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T1 - Non-T, non-B acute lymphoblastic leukemia (L3) with t(8;22) and two 14q+ chromosomes

AU - Chaganti, R. S.K.

AU - Jhanwar, Suresh C.

AU - Arlin, Zalmen

AU - Koziner, Benjamin

AU - Ambati, Appaji

AU - Andreeff, Michael

AU - Clarkson, Bayard D.

PY - 1983/9

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N2 - A patient with L3 leukemia is reported whose leukemic cells were characterized cytogenetically by a duplication of the long arm segment 1q25→q42, trisomy for chromosome 7, t(8;22)(q24;q11), and two 14q+ chromosomes. Immunologic marker analysis revealed the leukemic cells to be of the non-T, non-B ("null") type. This observation, when considered in conjunction with a previous report of heterogeneity in cell lineages of L3 leukemias, raises the possibility of some lymphoid neoplasms arising in stem cells.

AB - A patient with L3 leukemia is reported whose leukemic cells were characterized cytogenetically by a duplication of the long arm segment 1q25→q42, trisomy for chromosome 7, t(8;22)(q24;q11), and two 14q+ chromosomes. Immunologic marker analysis revealed the leukemic cells to be of the non-T, non-B ("null") type. This observation, when considered in conjunction with a previous report of heterogeneity in cell lineages of L3 leukemias, raises the possibility of some lymphoid neoplasms arising in stem cells.

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Non-T, non-B acute lymphoblastic leukemia (L3) with t(8;22) and two 14q+ chromosomes

Abstract

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