Nonclassical SNAPFL analogue as a Cy5 resonance energy transfer partner

Sung Hoon Kim; Julian R. Gunther; John A. Katzenellenbogen

doi:10.1021/ol801907b

Nonclassical SNAPFL analogue as a Cy5 resonance energy transfer partner

Sung Hoon Kim, Julian R. Gunther, John A. Katzenellenbogen

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

(Graph Presented) We have synthesized a new SNAPFL analogue (1) that exhibits a large Stokes shift (78 nm) (abs. 542 nm, em. 620 nm) and a good quantum yield. Because of the large overlap between the emission spectrum of 1 and the absorption spectrum of Cy5, 1 functions well as a fluorescence donor to Cy5 and has been used in FRET-based experiments using estrogen receptor site-specifically labeled with Cy5 and a receptor ligand conjugated to SNAPFL.

Original language	English (US)
Pages (from-to)	4931-4934
Number of pages	4
Journal	Organic Letters
Volume	10
Issue number	21
DOIs	https://doi.org/10.1021/ol801907b
State	Published - 2008
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Nonclassical SNAPFL analogue as a Cy5 resonance energy transfer partner",

abstract = "(Graph Presented) We have synthesized a new SNAPFL analogue (1) that exhibits a large Stokes shift (78 nm) (abs. 542 nm, em. 620 nm) and a good quantum yield. Because of the large overlap between the emission spectrum of 1 and the absorption spectrum of Cy5, 1 functions well as a fluorescence donor to Cy5 and has been used in FRET-based experiments using estrogen receptor site-specifically labeled with Cy5 and a receptor ligand conjugated to SNAPFL.",

author = "Kim, {Sung Hoon} and Gunther, {Julian R.} and Katzenellenbogen, {John A.}",

year = "2008",

doi = "10.1021/ol801907b",

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AU - Kim, Sung Hoon

AU - Gunther, Julian R.

AU - Katzenellenbogen, John A.

PY - 2008

Y1 - 2008

N2 - (Graph Presented) We have synthesized a new SNAPFL analogue (1) that exhibits a large Stokes shift (78 nm) (abs. 542 nm, em. 620 nm) and a good quantum yield. Because of the large overlap between the emission spectrum of 1 and the absorption spectrum of Cy5, 1 functions well as a fluorescence donor to Cy5 and has been used in FRET-based experiments using estrogen receptor site-specifically labeled with Cy5 and a receptor ligand conjugated to SNAPFL.

AB - (Graph Presented) We have synthesized a new SNAPFL analogue (1) that exhibits a large Stokes shift (78 nm) (abs. 542 nm, em. 620 nm) and a good quantum yield. Because of the large overlap between the emission spectrum of 1 and the absorption spectrum of Cy5, 1 functions well as a fluorescence donor to Cy5 and has been used in FRET-based experiments using estrogen receptor site-specifically labeled with Cy5 and a receptor ligand conjugated to SNAPFL.

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JF - Organic Letters

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Nonclassical SNAPFL analogue as a Cy5 resonance energy transfer partner

Abstract

ASJC Scopus subject areas

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