Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer

Susan P. Lees-Miller; Tara L. Beattie; John A. Tainer

doi:10.1038/nsmb.3240

Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer

Susan P. Lees-Miller, Tara L. Beattie, John A. Tainer

Molecular & Cellular Oncology

Research output: Contribution to journal › Short survey › peer-review

13 Scopus citations

Abstract

The noncoding RNA LINP1 acts as a scaffold that links Ku and DNA-PKcs and enables efficient DNA double-strand-break repair through nonhomologous end joining (NHEJ), thereby enhancing the resistance of triple-negative breast cancer cells to radiation and chemotherapies.

Original language	English (US)
Pages (from-to)	509-510
Number of pages	2
Journal	Nature Structural and Molecular Biology
Volume	23
Issue number	6
DOIs	https://doi.org/10.1038/nsmb.3240
State	Published - Jun 7 2016

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1038/nsmb.3240

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title = "Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer",

abstract = "The noncoding RNA LINP1 acts as a scaffold that links Ku and DNA-PKcs and enables efficient DNA double-strand-break repair through nonhomologous end joining (NHEJ), thereby enhancing the resistance of triple-negative breast cancer cells to radiation and chemotherapies.",

author = "Lees-Miller, {Susan P.} and Beattie, {Tara L.} and Tainer, {John A.}",

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AU - Lees-Miller, Susan P.

AU - Beattie, Tara L.

AU - Tainer, John A.

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N2 - The noncoding RNA LINP1 acts as a scaffold that links Ku and DNA-PKcs and enables efficient DNA double-strand-break repair through nonhomologous end joining (NHEJ), thereby enhancing the resistance of triple-negative breast cancer cells to radiation and chemotherapies.

AB - The noncoding RNA LINP1 acts as a scaffold that links Ku and DNA-PKcs and enables efficient DNA double-strand-break repair through nonhomologous end joining (NHEJ), thereby enhancing the resistance of triple-negative breast cancer cells to radiation and chemotherapies.

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JO - Nature Structural and Molecular Biology

JF - Nature Structural and Molecular Biology

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Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer

Abstract

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