TY - JOUR
T1 - Nonlinearity parameter for tissue-mimicking materials
AU - Dong, Fang
AU - Madsen, Ernest L.
AU - MacDonald, Michael C.
AU - Zagzebski, James A.
N1 - Funding Information:
This work was supported in part by a Richard B. Mazess Fellowship from the University of Wisconsin and by National Institute of Health grants R42GM54377 and R01-CA39224. The authors also are grateful to Gary Frank for helping make the tissue-mimicking materials used in this work.
PY - 1999/6
Y1 - 1999/6
N2 - A finite amplitude insert-substitution method has been used to determine the ultrasonic nonlinearity parameter B/A of nine versions of water-based, macroscopically uniform ultrasonically tissue-mimicking (TM) nonfat and fat materials. In this method, the amplitude of the second harmonic following transmission through degassed distilled water with known B/A (B/A = 5.2) and the amplitude of the second harmonic following transmission through the unknown sample are measured. The ratio of these amplitudes allows calculation of the B/A of the sample. Measured B/A values of the nonfat materials range from 5.6 to 6.6. These values compare favorably with published values for nonfat soft tissues. In contrast, the measured B/A values for two tissue-mimicking fat materials are 9.8 and 11.1; these two values represent the low and high end of B/A for most fresh fatty tissues. For comparison, B/A was measured for two commonly available uniform materials, corn oil and ethylene glycol, and the results are in good agreement with published values.
AB - A finite amplitude insert-substitution method has been used to determine the ultrasonic nonlinearity parameter B/A of nine versions of water-based, macroscopically uniform ultrasonically tissue-mimicking (TM) nonfat and fat materials. In this method, the amplitude of the second harmonic following transmission through degassed distilled water with known B/A (B/A = 5.2) and the amplitude of the second harmonic following transmission through the unknown sample are measured. The ratio of these amplitudes allows calculation of the B/A of the sample. Measured B/A values of the nonfat materials range from 5.6 to 6.6. These values compare favorably with published values for nonfat soft tissues. In contrast, the measured B/A values for two tissue-mimicking fat materials are 9.8 and 11.1; these two values represent the low and high end of B/A for most fresh fatty tissues. For comparison, B/A was measured for two commonly available uniform materials, corn oil and ethylene glycol, and the results are in good agreement with published values.
KW - B/A
KW - Nonlinearity parameter
KW - Second harmonic
KW - Tissue-mimicking materials
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U2 - 10.1016/S0301-5629(99)00016-2
DO - 10.1016/S0301-5629(99)00016-2
M3 - Article
C2 - 10414900
AN - SCOPUS:0033011165
SN - 0301-5629
VL - 25
SP - 831
EP - 838
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 5
ER -