Abstract
Radioimmunoassays that detect pyrimidine-pyrimidone (6-4) photoproducts and cyclobutane dimers were used to determine the relative induction of these photoproducts in nucleosomal (core) and internucleosomal (linker) DNA in human cell chromatin irradiated with UV light. Cyclobutane dimers were formed in equal amounts/nucleotide in core and linker DNA, whereas (6-4) photoproducts occurred with 6-fold greater frequency/nucleotide in linker DNA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5353-5356 |
| Number of pages | 4 |
| Journal | Journal of Biological Chemistry |
| Volume | 265 |
| Issue number | 10 |
| State | Published - 1990 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology