Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors

W. T. Schroeder; L. Y. Chao; D. D. Dao; L. C. Strong; S. Pathak; V. Riccardi; W. H. Lewis; G. F. Saunders

Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors

W. T. Schroeder, L. Y. Chao, D. D. Dao, L. C. Strong, S. Pathak, V. Riccardi, W. H. Lewis, G. F. Saunders

Genetics

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216 Scopus citations

Abstract

A series of gene probes for chromosome 11 has been used to study the genetic events associated with the development of Wilms tumor. Examination of DNA samples from (1) five patients with Wilms tumor in whom the tumors showed loss of chromosome 11 alleles and (2) their parents indicate that alleles lost in the tumors are of maternal origin. These data suggest that the parental derivation of chromosome 11 alleles lost in these Wilms tumors is not random.

Original language	English (US)
Pages (from-to)	413-420
Number of pages	8
Journal	American journal of human genetics
Volume	40
Issue number	5
State	Published - 1987

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Cite this

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title = "Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors",

abstract = "A series of gene probes for chromosome 11 has been used to study the genetic events associated with the development of Wilms tumor. Examination of DNA samples from (1) five patients with Wilms tumor in whom the tumors showed loss of chromosome 11 alleles and (2) their parents indicate that alleles lost in the tumors are of maternal origin. These data suggest that the parental derivation of chromosome 11 alleles lost in these Wilms tumors is not random.",

author = "Schroeder, {W. T.} and Chao, {L. Y.} and Dao, {D. D.} and Strong, {L. C.} and S. Pathak and V. Riccardi and Lewis, {W. H.} and Saunders, {G. F.}",

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T1 - Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors

AU - Schroeder, W. T.

AU - Chao, L. Y.

AU - Dao, D. D.

AU - Strong, L. C.

AU - Pathak, S.

AU - Riccardi, V.

AU - Lewis, W. H.

AU - Saunders, G. F.

PY - 1987

Y1 - 1987

N2 - A series of gene probes for chromosome 11 has been used to study the genetic events associated with the development of Wilms tumor. Examination of DNA samples from (1) five patients with Wilms tumor in whom the tumors showed loss of chromosome 11 alleles and (2) their parents indicate that alleles lost in the tumors are of maternal origin. These data suggest that the parental derivation of chromosome 11 alleles lost in these Wilms tumors is not random.

AB - A series of gene probes for chromosome 11 has been used to study the genetic events associated with the development of Wilms tumor. Examination of DNA samples from (1) five patients with Wilms tumor in whom the tumors showed loss of chromosome 11 alleles and (2) their parents indicate that alleles lost in the tumors are of maternal origin. These data suggest that the parental derivation of chromosome 11 alleles lost in these Wilms tumors is not random.

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C2 - 2883892

AN - SCOPUS:0023256838

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JF - American journal of human genetics

IS - 5

ER -

Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors

Abstract

ASJC Scopus subject areas

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