NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/ß-catenin pathway

Jin Ju Lei; Rou Jun Peng; Bo Hua Kuang; Zhong Yu Yuan; Tao Qin; Wen Sheng Liu; Yun Miao Guo; Hui Qiong Han; Yi Fan Lian; Cheng Cheng Deng; Hao Jiong Zhang; Li Zhen Chen; Qi Sheng Feng; Miao Xu; Lin Feng; Jin Xin Bei; Yi Xin Zeng

doi:10.18632/oncotarget.4573

NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/ß-catenin pathway

Jin Ju Lei, Rou Jun Peng, Bo Hua Kuang, Zhong Yu Yuan, Tao Qin, Wen Sheng Liu, Yun Miao Guo, Hui Qiong Han, Yi Fan Lian, Cheng Cheng Deng, Hao Jiong Zhang, Li Zhen Chen, Qi Sheng Feng, Miao Xu, Lin Feng, Jin Xin Bei, Yi Xin Zeng

Experimental Radiation Oncology

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

NOP14, which is functionally conserved among eukaryotes, has been implicated in cancer development. Here, we show that NOP14 is poorly expressed in breast cancer cells and invasive breast cancer tissues. In vivo and in vitro studies indicated that NOP14 suppressed the tumorigenesis and metastasis of breast cancer cells. Further investigations revealed that NOP14 enhanced ERa expression and inhibited the Wnt/ß-catenin pathway by up-regulating NRIP1 expression. Survival analysis indicated that low NOP14 expression was significantly associated with poor overall survival (P = 0.0006) and disease-free survival (P = 0.0007), suggesting that NOP14 is a potential prognostic factor in breast cancer. Taken together, our findings reveal that NOP14 may suppress breast cancer progression and provide new insights into the development of targeted therapeutic agents for breast cancer.

Original language	English (US)
Pages (from-to)	1-14
Number of pages	14
Journal	Oncotarget
Volume	6
Issue number	28
DOIs	https://doi.org/10.18632/oncotarget.4573
State	Published - 2015

Keywords

Breast cancer
NOP14
NRIP1
Wnt/ß-catenin pathway

ASJC Scopus subject areas

Oncology

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10.18632/oncotarget.4573

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title = "NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/{\ss}-catenin pathway",

abstract = "NOP14, which is functionally conserved among eukaryotes, has been implicated in cancer development. Here, we show that NOP14 is poorly expressed in breast cancer cells and invasive breast cancer tissues. In vivo and in vitro studies indicated that NOP14 suppressed the tumorigenesis and metastasis of breast cancer cells. Further investigations revealed that NOP14 enhanced ERa expression and inhibited the Wnt/{\ss}-catenin pathway by up-regulating NRIP1 expression. Survival analysis indicated that low NOP14 expression was significantly associated with poor overall survival (P = 0.0006) and disease-free survival (P = 0.0007), suggesting that NOP14 is a potential prognostic factor in breast cancer. Taken together, our findings reveal that NOP14 may suppress breast cancer progression and provide new insights into the development of targeted therapeutic agents for breast cancer.",

keywords = "Breast cancer, NOP14, NRIP1, Wnt/{\ss}-catenin pathway",

author = "Lei, {Jin Ju} and Peng, {Rou Jun} and Kuang, {Bo Hua} and Yuan, {Zhong Yu} and Tao Qin and Liu, {Wen Sheng} and Guo, {Yun Miao} and Han, {Hui Qiong} and Lian, {Yi Fan} and Deng, {Cheng Cheng} and Zhang, {Hao Jiong} and Chen, {Li Zhen} and Feng, {Qi Sheng} and Miao Xu and Lin Feng and Bei, {Jin Xin} and Zeng, {Yi Xin}",

year = "2015",

doi = "10.18632/oncotarget.4573",

language = "English (US)",

volume = "6",

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T1 - NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/ß-catenin pathway

AU - Lei, Jin Ju

AU - Peng, Rou Jun

AU - Kuang, Bo Hua

AU - Yuan, Zhong Yu

AU - Qin, Tao

AU - Liu, Wen Sheng

AU - Guo, Yun Miao

AU - Han, Hui Qiong

AU - Lian, Yi Fan

AU - Deng, Cheng Cheng

AU - Zhang, Hao Jiong

AU - Chen, Li Zhen

AU - Feng, Qi Sheng

AU - Xu, Miao

AU - Feng, Lin

AU - Bei, Jin Xin

AU - Zeng, Yi Xin

PY - 2015

Y1 - 2015

N2 - NOP14, which is functionally conserved among eukaryotes, has been implicated in cancer development. Here, we show that NOP14 is poorly expressed in breast cancer cells and invasive breast cancer tissues. In vivo and in vitro studies indicated that NOP14 suppressed the tumorigenesis and metastasis of breast cancer cells. Further investigations revealed that NOP14 enhanced ERa expression and inhibited the Wnt/ß-catenin pathway by up-regulating NRIP1 expression. Survival analysis indicated that low NOP14 expression was significantly associated with poor overall survival (P = 0.0006) and disease-free survival (P = 0.0007), suggesting that NOP14 is a potential prognostic factor in breast cancer. Taken together, our findings reveal that NOP14 may suppress breast cancer progression and provide new insights into the development of targeted therapeutic agents for breast cancer.

AB - NOP14, which is functionally conserved among eukaryotes, has been implicated in cancer development. Here, we show that NOP14 is poorly expressed in breast cancer cells and invasive breast cancer tissues. In vivo and in vitro studies indicated that NOP14 suppressed the tumorigenesis and metastasis of breast cancer cells. Further investigations revealed that NOP14 enhanced ERa expression and inhibited the Wnt/ß-catenin pathway by up-regulating NRIP1 expression. Survival analysis indicated that low NOP14 expression was significantly associated with poor overall survival (P = 0.0006) and disease-free survival (P = 0.0007), suggesting that NOP14 is a potential prognostic factor in breast cancer. Taken together, our findings reveal that NOP14 may suppress breast cancer progression and provide new insights into the development of targeted therapeutic agents for breast cancer.

KW - Breast cancer

KW - NOP14

KW - NRIP1

KW - Wnt/ß-catenin pathway

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NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/ß-catenin pathway

Abstract

Keywords

ASJC Scopus subject areas

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