Normal glucocorticoid receptor numbers in a child with glucocorticoid-resistant relapsed acute lymphocytic leukemia

Robert J. Wells, Kathryn Mascaro, Peter C.M. Young, Arthur J. Provisor, Robert E. Cleary, Robert L. Baehner

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Glucocorticoid receptors were quantified in circulating lymphoblasts from a child with relapsed acute lymphocytic leukemia refractory to multiple glucocorticoid containing drug regimens. The number of receptor sites in this patient’s lymphoblasts was found to be similar to the number of receptor sites in lymphoblasts from a group of newly diagnosed children with acute lymphocytic leukemia. This patient differs from previous reported cases of relapsed acute lymphocytic leukemia in that all previous relapsed patients with normal receptor numbers obtained complete remissions when glucocorticoid containing treatment regimens were employed.

Original languageEnglish (US)
Pages (from-to)3-7
Number of pages5
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume3
Issue number1
StatePublished - 1981

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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