Not so fast: Tumor cells resisting death drive CAR T-cell dysfunction

Michael R. Green; Sattva S. Neelapu

doi:10.1158/2159-8290.CD-20-0037

Not so fast: Tumor cells resisting death drive CAR T-cell dysfunction

Michael R. Green, Sattva S. Neelapu

Lymphoma-Myeloma

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

In this issue, Singh and colleagues describe a novel tumor-intrinsic mechanism of resistance to chimeric antigen receptor (CAR) T-cell therapy targeting CD19 in B-cell malignancies. They show that reduced expression of death receptor genes in the tumors mediates resistance to killing by CAR T cells, leads to progressive CAR T-cell dysfunction, and is associated with unfavorable clinical outcome in patients.

Original language	English (US)
Pages (from-to)	492-497
Number of pages	6
Journal	Cancer discovery
Volume	10
Issue number	4
DOIs	https://doi.org/10.1158/2159-8290.CD-20-0037
State	Published - Apr 2020

ASJC Scopus subject areas

Oncology

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10.1158/2159-8290.CD-20-0037

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title = "Not so fast: Tumor cells resisting death drive CAR T-cell dysfunction",

abstract = "In this issue, Singh and colleagues describe a novel tumor-intrinsic mechanism of resistance to chimeric antigen receptor (CAR) T-cell therapy targeting CD19 in B-cell malignancies. They show that reduced expression of death receptor genes in the tumors mediates resistance to killing by CAR T cells, leads to progressive CAR T-cell dysfunction, and is associated with unfavorable clinical outcome in patients.",

author = "Green, {Michael R.} and Neelapu, {Sattva S.}",

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AB - In this issue, Singh and colleagues describe a novel tumor-intrinsic mechanism of resistance to chimeric antigen receptor (CAR) T-cell therapy targeting CD19 in B-cell malignancies. They show that reduced expression of death receptor genes in the tumors mediates resistance to killing by CAR T cells, leads to progressive CAR T-cell dysfunction, and is associated with unfavorable clinical outcome in patients.

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Not so fast: Tumor cells resisting death drive CAR T-cell dysfunction

Abstract

ASJC Scopus subject areas

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