@inbook{bb90677ab8b54b1eb35e11ec3645c985,
title = "Novel approaches for chemosensitization of breast cancer cells: The E1A story",
abstract = "The adenoviral E1A-mediated sensitization to a variety of anti-cancer drug-induced apoptosis is a well-established phenomenon on different types of cell systems. However, the mechanisms underlying E1A-mediated chemosensitization are still not fully understood. Recent studies demonstrate that E1A-mediated sensitization to drug-induced apoptosis can occur via multiple pathways; some of which depend on the expression of functional p53 and/or p19ARF proteins, while some are not. In human breast cancer cells with Her-2/neu overexpression, which usually are more resistance to anti-cancer drugs than cells without Her-2/neu overexpression, may be sensitized through E1A-mediated downregulation of Her-2/neu. Alternatively, E1A can induce sensitization to anticancer drugs in cancer cells or normal diploid fibroblast cells through upregulating the expression of caspase proenzymes, or downregulating the activity of a critical survival factor Akt and/or upregulating the activities of a pro-apoptotic kinase p38 and a protein phosphatase PP2A, etc. This review summarizes these progresses and proposes a plausible feed-forward model for E1A-mediated chemosensitization in human breast cancer cells.",
author = "Yong Liao and Dihua Yu and Hung, {Mien Chie}",
year = "2007",
doi = "10.1007/978-0-387-74039-3_11",
language = "English (US)",
isbn = "9780387740379",
series = "Advances in Experimental Medicine and Biology",
pages = "144--169",
editor = "Dihua Yu and Mien-Chie Hung",
booktitle = "Breast Cancer Chemosensitivity",
}