Abstract
Immunotherapy is a promising therapeutic strategy in the treatment of lymphoma. The programmed death-1 (PD-1)/PD-ligand immune checkpoint pathway has been manipulated by tumor cells and serves as a mechanism of tumor evasion from the anti-tumor immune response. The recent development of anti-PD-1 antibodies has offered a therapeutic strategy for restoring the function of exhausted antigen-specific T cells and enhancing the endogenous anti-tumor immunity. We review the clinical studies demonstrating efficacy and safety of PD-1 antibodies in relapsed/refractory Hodgkin, follicular, and diffuse large B cell lymphoma. Principles learned in the development of immune checkpoint blockade provide the foundation for immunotherapy under clinical investigation.
Original language | English (US) |
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Article number | 2 |
Journal | Current oncology reports |
Volume | 17 |
Issue number | 7 |
DOIs | |
State | Published - Jul 22 2015 |
Keywords
- Checkpoint
- Lymphoma
- Monoclonal antibody
- Programmed death-1
ASJC Scopus subject areas
- Oncology