TY - JOUR
T1 - Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors
AU - Civelli, Olivier
AU - Nothacker, Hans Peter
AU - Saito, Yumiko
AU - Wang, Zhiwei
AU - Lin, Steven H.S.
AU - Reinscheid, Rainer K.
N1 - Funding Information:
We wish to thank S.D. Clark and L. Tamura for review of the manuscript. The work done in the author's laboratory was supported by a grant from NIH MH60231 (to O.C.), from the BioStar program S97-107 (to O.C.) and from the Eric and Lila Nelson Chair in Neuropharmacology.
PY - 2001/4/1
Y1 - 2001/4/1
N2 - The 'orphan' G-protein-coupled receptors (GPCRs) are cloned GPCRs that bind unknown ligands. Since 1995, nineteen orphan GPCRs have been used as targets to identify and isolate their natural ligands via the application of the 'orphan receptor strategy'. These ligands are peptides, lipids or biogenic amines, and act as transmitter molecules. One nucleotide-sugar derivative and six peptides or peptide families identified through this strategy are novel and have already enriched our understanding of various brain functions.
AB - The 'orphan' G-protein-coupled receptors (GPCRs) are cloned GPCRs that bind unknown ligands. Since 1995, nineteen orphan GPCRs have been used as targets to identify and isolate their natural ligands via the application of the 'orphan receptor strategy'. These ligands are peptides, lipids or biogenic amines, and act as transmitter molecules. One nucleotide-sugar derivative and six peptides or peptide families identified through this strategy are novel and have already enriched our understanding of various brain functions.
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U2 - 10.1016/S0166-2236(00)01763-X
DO - 10.1016/S0166-2236(00)01763-X
M3 - Review article
C2 - 11250008
AN - SCOPUS:0035313899
SN - 0166-2236
VL - 24
SP - 230
EP - 237
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 4
ER -