Abstract
The standard of care treatment for glioblastoma is surgical resection followed by radiotherapy to 60 Gy with concurrent and adjuvant temozolomide with or without tumor-treating fields. Advanced imaging techniques are under evaluation to better guide radiotherapy target volume delineation and allow for dose escalation. Particle therapy, in the form of protons, carbon ions, and boron neutron capture therapy, are being assessed as strategies to improve the radiotherapeutic ratio. Stereotactic, hypofractionated, pulsed-reduced dose-rate, and particle radiotherapy are re-irradiation techniques each uniquely suited for different clinical scenarios. Novel radiotherapy approaches, such as FLASH, represent promising advancements in radiotherapy for glioblastoma.
Original language | English (US) |
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Pages (from-to) | 211-223 |
Number of pages | 13 |
Journal | Neurosurgery clinics of North America |
Volume | 32 |
Issue number | 2 |
DOIs | |
State | Published - Apr 2021 |
Externally published | Yes |
Keywords
- Carbon ions
- GBM
- Glioblastoma
- Protons
- Radiation therapy
- Radiotherapy
- Trials
ASJC Scopus subject areas
- Surgery
- Clinical Neurology