Nuclear factor-ΚB: A transcription factor for all seasons

Bharat B. Aggarwal

doi:10.1517/14728222.11.2.109

Nuclear factor-ΚB: A transcription factor for all seasons

Bharat B. Aggarwal

Experimental Therapeutics

Research output: Contribution to journal › Editorial › peer-review

12 Scopus citations

Abstract

NF-κB, first discovered in 1986 in the nucleus of B cells as an immunoglobulin-Κ light chain enhancer, is today known as a transcription factor that is ubiquitously present in all cell types (not just B cells). It is conserved from drosophila to man, resides in the cytoplasm (not nucleus) in the resting state and binds to the promoter of > 400 different genes (not just immunoglobulin). Both NF-ΚB and TNF are essential components of the immune system, with their critical physiological role being in the immune defense.

Original language	English (US)
Pages (from-to)	109-110
Number of pages	2
Journal	Expert Opinion on Therapeutic Targets
Volume	11
Issue number	2
DOIs	https://doi.org/10.1517/14728222.11.2.109
State	Published - Feb 2007

Keywords

NF-ΚB
TNF

ASJC Scopus subject areas

Molecular Medicine
General Biochemistry, Genetics and Molecular Biology

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10.1517/14728222.11.2.109

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title = "Nuclear factor-ΚB: A transcription factor for all seasons",

abstract = "NF-κB, first discovered in 1986 in the nucleus of B cells as an immunoglobulin-Κ light chain enhancer, is today known as a transcription factor that is ubiquitously present in all cell types (not just B cells). It is conserved from drosophila to man, resides in the cytoplasm (not nucleus) in the resting state and binds to the promoter of > 400 different genes (not just immunoglobulin). Both NF-ΚB and TNF are essential components of the immune system, with their critical physiological role being in the immune defense.",

keywords = "NF-ΚB, TNF",

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note = "Funding Information: This work was supported by a grant from the Clayton Foundation for Research, National Institutes of Health P01 grant CA91844 on lung chemoprevention.",

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N2 - NF-κB, first discovered in 1986 in the nucleus of B cells as an immunoglobulin-Κ light chain enhancer, is today known as a transcription factor that is ubiquitously present in all cell types (not just B cells). It is conserved from drosophila to man, resides in the cytoplasm (not nucleus) in the resting state and binds to the promoter of > 400 different genes (not just immunoglobulin). Both NF-ΚB and TNF are essential components of the immune system, with their critical physiological role being in the immune defense.

AB - NF-κB, first discovered in 1986 in the nucleus of B cells as an immunoglobulin-Κ light chain enhancer, is today known as a transcription factor that is ubiquitously present in all cell types (not just B cells). It is conserved from drosophila to man, resides in the cytoplasm (not nucleus) in the resting state and binds to the promoter of > 400 different genes (not just immunoglobulin). Both NF-ΚB and TNF are essential components of the immune system, with their critical physiological role being in the immune defense.

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KW - TNF

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Nuclear factor-ΚB: A transcription factor for all seasons

Abstract

Keywords

ASJC Scopus subject areas

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