TY - JOUR
T1 - Obesity, anemia, and cardiovascular risk in patients with chronic kidney disease
T2 - Overview and pathophysiologic insights
AU - Miller, Andrew C.
AU - Smaglo, Brandon
AU - McFarlane, Samy I.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2009
Y1 - 2009
N2 - Obesity is a well-established risk factor for cardiovascular disease (CVD) and is increasingly being recognized as a risk factor for chronic kidney disease (CKD). Anemia that is associated with rapid CKD progression is also associated with increased CVD risk. The common soil hypothesis linking obesity, anemia, CKD, and CVD includes increased inflammation and oxidative stress. We present an overview of CKD and CVD risk associated with obesity and anemia highlighting the pathogenetic pathways linking these rapidly growing disorders. We also discuss the therapeutic strategies for obesity reduction and anemia treatment and their impact on CVD and CKD risk, highlighting the contemporary issues and questions raised by recent clinical trials.
AB - Obesity is a well-established risk factor for cardiovascular disease (CVD) and is increasingly being recognized as a risk factor for chronic kidney disease (CKD). Anemia that is associated with rapid CKD progression is also associated with increased CVD risk. The common soil hypothesis linking obesity, anemia, CKD, and CVD includes increased inflammation and oxidative stress. We present an overview of CKD and CVD risk associated with obesity and anemia highlighting the pathogenetic pathways linking these rapidly growing disorders. We also discuss the therapeutic strategies for obesity reduction and anemia treatment and their impact on CVD and CKD risk, highlighting the contemporary issues and questions raised by recent clinical trials.
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U2 - 10.1007/s12170-009-0018-7
DO - 10.1007/s12170-009-0018-7
M3 - Article
AN - SCOPUS:84873512147
SN - 1932-9520
VL - 3
SP - 102
EP - 108
JO - Current Cardiovascular Risk Reports
JF - Current Cardiovascular Risk Reports
IS - 2
ER -