TY - JOUR
T1 - Obesity Is a Risk Factor Associated with H. pylori-negative MALT Lymphoma of Stomach
AU - Mai, Brenda
AU - Friscia, Michaelangelo
AU - Elzamly, Shaimaa
AU - Thomas-Ogunniyi, Jaiyeola
AU - Wahed, Amer
AU - Nguyen, Andy
AU - Hu, Zhihong
AU - Cai, Zhenjian
AU - Chen, Lei
N1 - Publisher Copyright:
© 2021 by the Association of Clinical Scientists, Inc.
PY - 2021
Y1 - 2021
N2 - Objective. More than 90% of gastric mucosa-associated lymphoid tissue (MALT) lymphomas are attributed to Helicobacter pylori infections. However, the pathogenesis of H. pylori-negative MALT lymphomas is controversial, and additional etiologies need to be investigated. Materials. A retrospective study of gastric MALT lymphoma cases over a 15-year period revealed 56 cases. The H. pylori status, clinical information, and body mass index (BMI) data were collected. The results of the urea breath test, serology, stool antigen, and previous biopsy results were documented. Results. The 56 cases had an average height of 166.57 cm (range, 147.3-190.5), weight of 83.98 kg (range 55-153.1), and body mass index (BMI) of 30.34 kg/m2 (range, 17.96-49.77). Twenty-one cases were H. pylori-positive (37.5%), with a mean BMI of 27.36 kg/m2 (range, 17.96-47.25), and BMI>30 kg/m2 in 5 (23.8%) patients. Thirty-five cases were H. pylori-negative, with a mean BMI of 31.90 kg/m2 (range, 18.17-49.77), and 20 (57.1%) having BMI>30 kg/m2. A Fisher’s exact test and two-tailed test showed a statistically significant difference between the two groups. Conclusion. Obesity leads to a baseline state of chronic inflammation and increased production of pro-inflammatory cytokines that can stimulate the lymphocytes, leading to lymphomatous proliferation. Our study suggests a potential correlation between obesity and the risk of development of primary gastric MALT lymphoma.
AB - Objective. More than 90% of gastric mucosa-associated lymphoid tissue (MALT) lymphomas are attributed to Helicobacter pylori infections. However, the pathogenesis of H. pylori-negative MALT lymphomas is controversial, and additional etiologies need to be investigated. Materials. A retrospective study of gastric MALT lymphoma cases over a 15-year period revealed 56 cases. The H. pylori status, clinical information, and body mass index (BMI) data were collected. The results of the urea breath test, serology, stool antigen, and previous biopsy results were documented. Results. The 56 cases had an average height of 166.57 cm (range, 147.3-190.5), weight of 83.98 kg (range 55-153.1), and body mass index (BMI) of 30.34 kg/m2 (range, 17.96-49.77). Twenty-one cases were H. pylori-positive (37.5%), with a mean BMI of 27.36 kg/m2 (range, 17.96-47.25), and BMI>30 kg/m2 in 5 (23.8%) patients. Thirty-five cases were H. pylori-negative, with a mean BMI of 31.90 kg/m2 (range, 18.17-49.77), and 20 (57.1%) having BMI>30 kg/m2. A Fisher’s exact test and two-tailed test showed a statistically significant difference between the two groups. Conclusion. Obesity leads to a baseline state of chronic inflammation and increased production of pro-inflammatory cytokines that can stimulate the lymphocytes, leading to lymphomatous proliferation. Our study suggests a potential correlation between obesity and the risk of development of primary gastric MALT lymphoma.
KW - Helicobacter pylori
KW - MALT lymphoma
KW - MALToma
KW - Mucosal associated lymphoid tissue lymphoma
KW - obesity
UR - http://www.scopus.com/inward/record.url?scp=85120720251&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85120720251&partnerID=8YFLogxK
M3 - Article
C2 - 34686502
AN - SCOPUS:85120720251
SN - 0091-7370
VL - 51
SP - 609
EP - 614
JO - Annals of clinical and laboratory science
JF - Annals of clinical and laboratory science
IS - 5
ER -