TY - JOUR
T1 - Observer agreement for small bowel ultrasound in Crohn’s disease
T2 - results from the METRIC trial
AU - METRIC study investigators
AU - Bhatnagar, Gauraang
AU - Quinn, Laura
AU - Higginson, Antony
AU - Plumb, Andrew
AU - Halligan, Steve
AU - Tolan, Damian
AU - Lapham, Roger
AU - Mallett, Susan
AU - Taylor, Stuart A.
AU - Dyer, Jade
AU - Veeramalla, Pranitha
AU - Tebbs, Sue
AU - Hibbert, Steve
AU - Ellis, Richard
AU - Thursby-Pelham, Fergus
AU - Beable, Richard
AU - Gibbons, Nicola
AU - Ward, Claire
AU - O’Connor, Anthony
AU - Lambie, Hannah
AU - Hyland, Rachel
AU - Scott, Nigel
AU - Quartey, Doris
AU - Scrimshaw, Deborah
AU - Bungay, Helen
AU - Betts, Maggie
AU - Fourie, Simona
AU - Ilangovan, Rajapandian
AU - Patel, Uday
AU - Mainta, Evgenia
AU - Lung, Phillip
AU - Johnston, Ian
AU - Naghibi, Mani
AU - Moorghen, Morgan
AU - Martinez, Adriana
AU - Porte, Francois
AU - Alexakis, Christopher
AU - Pilcher, James
AU - Rahman, Anisur
AU - Vlahos, Jonny
AU - Greenhalgh, Rebecca
AU - Wale, Anita
AU - Beeston, Teresita
AU - Piga, Wivijin
AU - Clemente, Joey
AU - Rahman, Farooq
AU - de Caro, Simona
AU - Mehta, Shameer
AU - Vega, Roser
AU - Jastrub, Roman
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Purpose: To prospectively evaluate interobserver agreement for small bowel ultrasound (SBUS) in newly diagnosed and relapsing Crohn’s disease. Methods: A subset of patients recruited to a prospective trial comparing the diagnostic accuracy of MR enterography and SBUS underwent a second SBUS performed by one of a pool of six practitioners, who recorded the presence, activity and location of small bowel and colonic disease. Detailed segmental mural and extra-mural observations were also scored. Interobserver variability was expressed as percentage agreement with a construct reference standard, split by patient cohort, grouping disease as present or absent. Prevalence adjusted bias adjusted kappa (PABAK), and simple percentage agreement between practitioners, irrespective of the reference standard, were calculated. Results: Thirty-eight patients (11 new diagnosis, 27 relapse) were recruited from two sites. Overall percentage agreement for small bowel disease presence against the consensus reference was 82% (52–95% (95%CI)), kappa coefficient (κ) 0.64, (substantial agreement) for new diagnosis and 81%, κ 0.63 (substantial agreement) for the relapsing cohort. Agreement for colonic disease presence was 64%, κ 0.27 (fair agreement) in new diagnosis and 78%,κ 0.56 (moderate agreement) in the relapsing cohort. Simple agreement between practitioners was 84% and 87% for small bowel and colonic disease presence respectively. Practitioners agreed on small bowel disease activity in 24/27 (89%) where both identified disease. Kappa agreement for detailed mural observations ranged from κ 0.00 to 1.00. Conclusion: There is substantial practitioner agreement for small bowel disease presence in newly diagnosed and relapsing CD patients, supporting wider dissemination of enteric US.
AB - Purpose: To prospectively evaluate interobserver agreement for small bowel ultrasound (SBUS) in newly diagnosed and relapsing Crohn’s disease. Methods: A subset of patients recruited to a prospective trial comparing the diagnostic accuracy of MR enterography and SBUS underwent a second SBUS performed by one of a pool of six practitioners, who recorded the presence, activity and location of small bowel and colonic disease. Detailed segmental mural and extra-mural observations were also scored. Interobserver variability was expressed as percentage agreement with a construct reference standard, split by patient cohort, grouping disease as present or absent. Prevalence adjusted bias adjusted kappa (PABAK), and simple percentage agreement between practitioners, irrespective of the reference standard, were calculated. Results: Thirty-eight patients (11 new diagnosis, 27 relapse) were recruited from two sites. Overall percentage agreement for small bowel disease presence against the consensus reference was 82% (52–95% (95%CI)), kappa coefficient (κ) 0.64, (substantial agreement) for new diagnosis and 81%, κ 0.63 (substantial agreement) for the relapsing cohort. Agreement for colonic disease presence was 64%, κ 0.27 (fair agreement) in new diagnosis and 78%,κ 0.56 (moderate agreement) in the relapsing cohort. Simple agreement between practitioners was 84% and 87% for small bowel and colonic disease presence respectively. Practitioners agreed on small bowel disease activity in 24/27 (89%) where both identified disease. Kappa agreement for detailed mural observations ranged from κ 0.00 to 1.00. Conclusion: There is substantial practitioner agreement for small bowel disease presence in newly diagnosed and relapsing CD patients, supporting wider dissemination of enteric US.
KW - Crohn disease
KW - Observer variation
KW - Prospective studies
KW - Ultrasonography
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U2 - 10.1007/s00261-020-02405-w
DO - 10.1007/s00261-020-02405-w
M3 - Article
C2 - 32037466
AN - SCOPUS:85079235817
SN - 2366-004X
VL - 45
SP - 3036
EP - 3045
JO - Abdominal Radiology
JF - Abdominal Radiology
IS - 10
ER -