TY - JOUR
T1 - Ocular adnexal diffuse large B-cell lymphoma
T2 - Local disease correlates with better outcomes
AU - Madge, S. N.
AU - Mccormick, A.
AU - Patel, I.
AU - Hatef, E.
AU - Menon, V.
AU - Prabhakaran, V. C.
AU - Irion, L.
AU - Bonshek, R.
AU - Honovar, S.
AU - Leatherbarrow, B.
AU - Esmaeli, B.
AU - Selva, D.
N1 - Funding Information:
Dr Simon Madge has received funding from the Royal College of Ophthalmologists, Pfizer, the Ethicon Foundation, and Advanced Medical Optics for unrestricted training in Adelaide. The sponsors had no role in the design or conduct of this research. Institutional review board approval was granted by the Royal Adelaide Hospital.
PY - 2010/6
Y1 - 2010/6
N2 - Purpose To describe the clinical, immunohistochemical and prognostic features, as well as outcomes of a large series of patients with orbital and periorbital diffuse large B-cell lymphoma (DLBCL).DesignThis study is a multicentre, retrospective non-comparative consecutive case series.Methods The setting for this study was institutional. A total of 37 consecutive patients identified from the institutions' databases with periorbital and orbital DLBCL were enrolled in the study. A retrospective chart review was used for observation. The main outcome measures were patient demographics, clinical features, imaging, immunohistochemical and histopathological data, treatments administered, and survival.Results A total of 20 out of 37 cases (54.1%) represented localised periorbital disease (group L), 11 of 37 (29.7%) had systemic disease at presentation with periorbital disease (group S1), and 6 of 37 (16.2%) had previous history of systemic lymphoma (group S2). In all, 28 out of 30 (93.3%) patients were CD20, 5 of 25 (20%) were CD3, and 11 of 11 (100%) were CD79a (varying denominators reflect the different numbers of patients tested). A total of 25 out of 32 patients (78.1%) received chemotherapy, 14 (43.8%) received rituxmab plus chemotherapy, and 19 (59.3%) received radiotherapy. Nine deaths occurred, one in group L (not lymphoma related), six in group S1, and two in group S2. Five-year Kaplan-Meier survival estimates were 55.9% for all cases, 90.9% for group L, 36.0% for group S1, and 0% for group S2. One-year progression-free survival estimates in groups S1 and S2 combined were 58.3% for patients treated with rituximab and 28.6% for those who were not.Conclusions To our knowledge, this report represents the largest series of patients with periorbital and orbital DLBCL in the literature. The difference in survival between groups L, S1 and S2 was striking, reflecting the grave prognosis of systemic DLBCL, but conversely the relatively optimistic outlook for patients with localised disease. Rituximab plus chemotherapy may be associated with increased survival.
AB - Purpose To describe the clinical, immunohistochemical and prognostic features, as well as outcomes of a large series of patients with orbital and periorbital diffuse large B-cell lymphoma (DLBCL).DesignThis study is a multicentre, retrospective non-comparative consecutive case series.Methods The setting for this study was institutional. A total of 37 consecutive patients identified from the institutions' databases with periorbital and orbital DLBCL were enrolled in the study. A retrospective chart review was used for observation. The main outcome measures were patient demographics, clinical features, imaging, immunohistochemical and histopathological data, treatments administered, and survival.Results A total of 20 out of 37 cases (54.1%) represented localised periorbital disease (group L), 11 of 37 (29.7%) had systemic disease at presentation with periorbital disease (group S1), and 6 of 37 (16.2%) had previous history of systemic lymphoma (group S2). In all, 28 out of 30 (93.3%) patients were CD20, 5 of 25 (20%) were CD3, and 11 of 11 (100%) were CD79a (varying denominators reflect the different numbers of patients tested). A total of 25 out of 32 patients (78.1%) received chemotherapy, 14 (43.8%) received rituxmab plus chemotherapy, and 19 (59.3%) received radiotherapy. Nine deaths occurred, one in group L (not lymphoma related), six in group S1, and two in group S2. Five-year Kaplan-Meier survival estimates were 55.9% for all cases, 90.9% for group L, 36.0% for group S1, and 0% for group S2. One-year progression-free survival estimates in groups S1 and S2 combined were 58.3% for patients treated with rituximab and 28.6% for those who were not.Conclusions To our knowledge, this report represents the largest series of patients with periorbital and orbital DLBCL in the literature. The difference in survival between groups L, S1 and S2 was striking, reflecting the grave prognosis of systemic DLBCL, but conversely the relatively optimistic outlook for patients with localised disease. Rituximab plus chemotherapy may be associated with increased survival.
KW - Large cell
KW - Lymphoma
KW - Orbit
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=77953560081&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953560081&partnerID=8YFLogxK
U2 - 10.1038/eye.2009.283
DO - 10.1038/eye.2009.283
M3 - Article
C2 - 19942938
AN - SCOPUS:77953560081
SN - 0950-222X
VL - 24
SP - 954
EP - 961
JO - Eye
JF - Eye
IS - 6
ER -