Office-based injection laryngoplasty in the irradiated larynx

Objectives/Hypothesis: To review the clinical results of office-based injection laryngoplasty with two different therapeutic materials in patients with vocal fold paralysis and history of radiation therapy to the larynx. Study Design: Retrospective study. Methods: Chart review of 11 patients who underwent office-based injection laryngoplasty with calcium hydroxylapatite or micronized Alloderm. All patients had a history of radiation therapy to the neck, with the larynx included in the radiation field. Voice analyses, clinical outcomes, and complications were reviewed. Efficacy of the procedure was evaluated by comparing pre- and postinjection mean phonation time (MPT) results from voice analysis data. Results: A total of 15 injections were performed in 11 patients with vocal fold paralysis (one females, 10 males, mean age 62 years). Data from voice analyses before and after the procedure were available for nine injections. The MPT was significantly increased among patients undergoing the procedure (P < .05). All procedures were successful, and only one self-limited complication was reported. Conclusions: Office-based injection laryngoplasty is a safe procedure with acceptable clinical results in patients with vocal fold paralysis who have a history of radiation therapy to the larynx.