We have studied the incorporation of various oligonucleotides (oligos) in liposomes. Some of these oligos are hydrophilic while others are lipophilic. Typically, the lipophilic oligos were incorporated at a higher efficiency than the hydrophilic oligos. Nonetheless, liposomes could increase the intracellular delivery of both of these types of oligos.
ASJC Scopus subject areas
- Pharmaceutical Science