TY - GEN
T1 - On sensitivity of molecular specific photoacoustic imaging using plasmonic gold nanoparticles
AU - Mallidi, Srivalleesha
AU - Joshi, Pratixa P.
AU - Sokolov, Konstantin
AU - Emelianov, Stanislav
PY - 2009
Y1 - 2009
N2 - Functionalized gold nanospheres undergo receptor mediated aggregation on cancer cells that overexpress the epidermal growth factor receptor (EGFR). This phenomenon leads to a red shift in the plasmon resonance frequency of the EGFR-targeted gold nanoparticles. Previously we demonstrated that highly selective detection of cancer cells can be achieved using the combination of multi-wavelength photoacoustic imaging and molecular specific gold nanoparticles. In this study, we use tissue models to evaluate the sensitivity of molecular specific photoacoustic imaging in detecting cancer cells labeled with EGFR-targeted gold nanoparticles. The results of our study indicate that highly sensitive detection of cancer cells is feasible using photoacoustic imaging and plasmonic gold nanoparticles.
AB - Functionalized gold nanospheres undergo receptor mediated aggregation on cancer cells that overexpress the epidermal growth factor receptor (EGFR). This phenomenon leads to a red shift in the plasmon resonance frequency of the EGFR-targeted gold nanoparticles. Previously we demonstrated that highly selective detection of cancer cells can be achieved using the combination of multi-wavelength photoacoustic imaging and molecular specific gold nanoparticles. In this study, we use tissue models to evaluate the sensitivity of molecular specific photoacoustic imaging in detecting cancer cells labeled with EGFR-targeted gold nanoparticles. The results of our study indicate that highly sensitive detection of cancer cells is feasible using photoacoustic imaging and plasmonic gold nanoparticles.
KW - Bioconjugated gold nanoparticles
KW - Molecular imaging
KW - Photoacoustic imaging
KW - Plasmon resonance coupling
UR - http://www.scopus.com/inward/record.url?scp=77950986488&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950986488&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2009.5333161
DO - 10.1109/IEMBS.2009.5333161
M3 - Conference contribution
C2 - 19964157
AN - SCOPUS:77950986488
SN - 9781424432967
T3 - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
SP - 6338
EP - 6340
BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PB - IEEE Computer Society
T2 - 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Y2 - 2 September 2009 through 6 September 2009
ER -