@article{44e4c8e47d4b4f3382ffeed834e38515,
title = "Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer",
abstract = "We identified new gene fusions in patients with lung cancer harboring the kinase domain of the NTRK1 gene that encodes the high-affinity nerve growth factor receptor (TRKA protein). Both the MPRIP-NTRK1 and CD74-NTRK1 fusions lead to constitutive TRKA kinase activity and are oncogenic. Treatment of cells expressing NTRK1 fusions with inhibitors of TRKA kinase activity inhibited autophosphorylation of TRKA and cell growth. Tumor samples from 3 of 91 patients with lung cancer (3.3%) without known oncogenic alterations assayed by next-generation sequencing or fluorescence in situ hybridization demonstrated evidence of NTRK1 gene fusions.",
author = "Aria Vaishnavi and Marzia Capelletti and Le, {Anh T.} and Severine Kako and Mohit Butaney and Dalia Ercan and Sakshi Mahale and Davies, {Kurtis D.} and Aisner, {Dara L.} and Pilling, {Amanda B.} and Berge, {Eamon M.} and Jhingook Kim and Hidefumi Sasaki and Park, {Seung Il} and Gregory Kryukov and Garraway, {Levi A.} and Hammerman, {Peter S.} and Julia Haas and Andrews, {Steven W.} and Doron Lipson and Stephens, {Philip J.} and Miller, {Vince A.} and Marileila Varella-Garcia and J{\"a}nne, {Pasi A.} and Doebele, {Robert C.}",
note = "Funding Information: This work was supported by the Colorado Bioscience Discovery Evaluation Grant Program, the National Institutes of Health (NIH) NCATS Colorado Clinical and Translational Sciences Institute Grant UL1 TR000154 (contents are the authors{\textquoteright} sole responsibility and do not necessarily represent official NIH views) and the Boettcher Foundation{\textquoteright}s Webb-Waring Biomedical Research Program (R.C.D.), as well as the Dana-Farber/Harvard Cancer Center Lung Cancer Specialized Programs of Research Excellence (SPORE) P50 CA090578 (P.A.J.), the Cammarata Family Foundation Research Fund (M.C. and P.A.J.), the Nirenberg Fellowship at the Dana-Farber Cancer Institute (M.C. and P.A.J.) and the University of Colorado Lung Cancer SPORE grant P50CA058187 and the US National Cancer Institute Cancer Center Support Grant P30CA46934 (M.V.-G.). Ba/F3 cells were a gift from D. Theodorescu (University of Colorado, Anschutz Medical Campus). The cell lines KM12, HCT116, HCT15, HT29 and SW837 were gifts from S.G. Eckhardt (University of Colorado, Anschutz Medical Campus). The cell lines H3122, H1650, H1299 and HCC78 were gifts from J.D. Minna (University of Texas Southwestern). Aythymic nude mice were a gift from J. DeGregori (University of Colorado, Anschutz Medical Campus).",
year = "2013",
month = nov,
doi = "10.1038/nm.3352",
language = "English (US)",
volume = "19",
pages = "1469--1472",
journal = "Nature medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "11",
}