Oncologic outcomes of surgically treated early-stage oropharyngeal squamous cell carcinoma

Jason I. Kass; Laureano Giraldez; William Gooding; Garret Choby; Seungwon Kim; Brett Miles; Marita Teng; Andrew G. Sikora; Jonas T. Johnson; Eugene N. Myers; Umamaheswar Duvvuri; Eric M. Genden; Robert L. Ferris

doi:10.1002/hed.24456

Oncologic outcomes of surgically treated early-stage oropharyngeal squamous cell carcinoma

Jason I. Kass, Laureano Giraldez, William Gooding, Garret Choby, Seungwon Kim, Brett Miles, Marita Teng, Andrew G. Sikora, Jonas T. Johnson, Eugene N. Myers, Umamaheswar Duvvuri, Eric M. Genden, Robert L. Ferris

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Background: The purpose of this study was to characterize oncologic outcomes in early (T1–T2, N0) and intermediate (T1–T2, N1) oropharyngeal squamous cell carcinoma (SCC) after surgery. Methods: Patients with oropharyngeal SCC treated with surgery were identified from 2 academic institutions. Results: Of 188 patients, 143 met the inclusion criteria. Eighty-six (60%) had T1 to T2 N0 and 57 (40%) had T1 to T2 N1 disease. Sixty-five patients (45%) underwent a robotic-assisted resection, whereas the remaining had transoral (n = 60; 42%), mandible-splitting (n = 11; 8%), or transhyoid approaches (n = 7; 5%). Human papillomavirus (HPV) status was known for 97 patients (68%), and 54 (55%) were HPV positive. Three-year recurrence-free survival (RFS) was 82% (95% confidence interval [CI] = 0.75–0.89). Since 2008, HPV infection was protective of recurrence (log-rank p =.0334). A single node did not increase the risk of recurrence (p =.467) or chance of a second primary (p =.175). Conclusion: Complete surgical resection is effective therapy for early and intermediate oropharyngeal SCC. HPV-negative patients were at increased risk for locoregional recurrence or second primary disease.

Original language	English (US)
Pages (from-to)	1467-1471
Number of pages	5
Journal	Head and Neck
Volume	38
Issue number	10
DOIs	https://doi.org/10.1002/hed.24456
State	Published - Oct 1 2016
Externally published	Yes

Keywords

oncologic outcomes
oropharyngeal squamous cell carcinoma
transoral robotic surgery

ASJC Scopus subject areas

Otorhinolaryngology

Access to Document

10.1002/hed.24456

Cite this

@article{7a8e4b780764447180d9246ced64fe61,

title = "Oncologic outcomes of surgically treated early-stage oropharyngeal squamous cell carcinoma",

abstract = "Background: The purpose of this study was to characterize oncologic outcomes in early (T1–T2, N0) and intermediate (T1–T2, N1) oropharyngeal squamous cell carcinoma (SCC) after surgery. Methods: Patients with oropharyngeal SCC treated with surgery were identified from 2 academic institutions. Results: Of 188 patients, 143 met the inclusion criteria. Eighty-six (60%) had T1 to T2 N0 and 57 (40%) had T1 to T2 N1 disease. Sixty-five patients (45%) underwent a robotic-assisted resection, whereas the remaining had transoral (n = 60; 42%), mandible-splitting (n = 11; 8%), or transhyoid approaches (n = 7; 5%). Human papillomavirus (HPV) status was known for 97 patients (68%), and 54 (55%) were HPV positive. Three-year recurrence-free survival (RFS) was 82% (95% confidence interval [CI] = 0.75–0.89). Since 2008, HPV infection was protective of recurrence (log-rank p =.0334). A single node did not increase the risk of recurrence (p =.467) or chance of a second primary (p =.175). Conclusion: Complete surgical resection is effective therapy for early and intermediate oropharyngeal SCC. HPV-negative patients were at increased risk for locoregional recurrence or second primary disease.",

keywords = "oncologic outcomes, oropharyngeal squamous cell carcinoma, transoral robotic surgery",

author = "Kass, {Jason I.} and Laureano Giraldez and William Gooding and Garret Choby and Seungwon Kim and Brett Miles and Marita Teng and Sikora, {Andrew G.} and Johnson, {Jonas T.} and Myers, {Eugene N.} and Umamaheswar Duvvuri and Genden, {Eric M.} and Ferris, {Robert L.}",

note = "Publisher Copyright: {\textcopyright} 2016 Wiley Periodicals, Inc.",

year = "2016",

month = oct,

day = "1",

doi = "10.1002/hed.24456",

language = "English (US)",

volume = "38",

pages = "1467--1471",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "Wiley-Liss Inc.",

number = "10",

}

TY - JOUR

T1 - Oncologic outcomes of surgically treated early-stage oropharyngeal squamous cell carcinoma

AU - Kass, Jason I.

AU - Giraldez, Laureano

AU - Gooding, William

AU - Choby, Garret

AU - Kim, Seungwon

AU - Miles, Brett

AU - Teng, Marita

AU - Sikora, Andrew G.

AU - Johnson, Jonas T.

AU - Myers, Eugene N.

AU - Duvvuri, Umamaheswar

AU - Genden, Eric M.

AU - Ferris, Robert L.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Background: The purpose of this study was to characterize oncologic outcomes in early (T1–T2, N0) and intermediate (T1–T2, N1) oropharyngeal squamous cell carcinoma (SCC) after surgery. Methods: Patients with oropharyngeal SCC treated with surgery were identified from 2 academic institutions. Results: Of 188 patients, 143 met the inclusion criteria. Eighty-six (60%) had T1 to T2 N0 and 57 (40%) had T1 to T2 N1 disease. Sixty-five patients (45%) underwent a robotic-assisted resection, whereas the remaining had transoral (n = 60; 42%), mandible-splitting (n = 11; 8%), or transhyoid approaches (n = 7; 5%). Human papillomavirus (HPV) status was known for 97 patients (68%), and 54 (55%) were HPV positive. Three-year recurrence-free survival (RFS) was 82% (95% confidence interval [CI] = 0.75–0.89). Since 2008, HPV infection was protective of recurrence (log-rank p =.0334). A single node did not increase the risk of recurrence (p =.467) or chance of a second primary (p =.175). Conclusion: Complete surgical resection is effective therapy for early and intermediate oropharyngeal SCC. HPV-negative patients were at increased risk for locoregional recurrence or second primary disease.

AB - Background: The purpose of this study was to characterize oncologic outcomes in early (T1–T2, N0) and intermediate (T1–T2, N1) oropharyngeal squamous cell carcinoma (SCC) after surgery. Methods: Patients with oropharyngeal SCC treated with surgery were identified from 2 academic institutions. Results: Of 188 patients, 143 met the inclusion criteria. Eighty-six (60%) had T1 to T2 N0 and 57 (40%) had T1 to T2 N1 disease. Sixty-five patients (45%) underwent a robotic-assisted resection, whereas the remaining had transoral (n = 60; 42%), mandible-splitting (n = 11; 8%), or transhyoid approaches (n = 7; 5%). Human papillomavirus (HPV) status was known for 97 patients (68%), and 54 (55%) were HPV positive. Three-year recurrence-free survival (RFS) was 82% (95% confidence interval [CI] = 0.75–0.89). Since 2008, HPV infection was protective of recurrence (log-rank p =.0334). A single node did not increase the risk of recurrence (p =.467) or chance of a second primary (p =.175). Conclusion: Complete surgical resection is effective therapy for early and intermediate oropharyngeal SCC. HPV-negative patients were at increased risk for locoregional recurrence or second primary disease.

KW - oncologic outcomes

KW - oropharyngeal squamous cell carcinoma

KW - transoral robotic surgery

UR - http://www.scopus.com/inward/record.url?scp=84987847984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84987847984&partnerID=8YFLogxK

U2 - 10.1002/hed.24456

DO - 10.1002/hed.24456

M3 - Article

C2 - 27080244

AN - SCOPUS:84987847984

SN - 1043-3074

VL - 38

SP - 1467

EP - 1471

JO - Head and Neck

JF - Head and Neck

IS - 10

ER -

Oncologic outcomes of surgically treated early-stage oropharyngeal squamous cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this