Abstract
Gliomas are the most common and aggressive brain tumors and despite advances in their therapeutic management they remain fatal. Radically, different therapeutic approaches are needed to treat this aggressive disease. Oncolytic viruses that intrinsically kill cancer cells or that have been genetically engineered to specifically destroy this population are becoming a viable therapeutic options for gliomas. A number of preclinical studies have demonstrated the efficacy of oncolytic viruses as a therapeutic strategy for gliomas. Those studies have led to a number of clinical trials using oncolytic virus for glioma treatment. In this chapter, we review the different viruses (adenovirus, herpes virus, parvovirus, poliovirus, reovirus, newcastle disease virus, retrovirus, and measles viruses) that have been evaluated preclinically and clinically for the treatment of glioma.
Original language | English (US) |
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Title of host publication | Gene Therapy in Neurological Disorders |
Publisher | Elsevier |
Pages | 357-384 |
Number of pages | 28 |
ISBN (Electronic) | 9780128098134 |
ISBN (Print) | 9780128098219 |
DOIs | |
State | Published - Jan 1 2018 |
Keywords
- Clinical trial
- Glioma
- Glioma treatment
- Oncolytic virus
ASJC Scopus subject areas
- General Medicine
- General Neuroscience