Ontogeny of the response of human peripheral blood T cells to glucocorticoids

Annemieke Kavelaars; Bernard Cats; Gerard H.A. Visser; Ben J.M. Zegers; Joost M. Bakker; Emmelien P. Van Rees; Cobi J. Heijnen

doi:10.1006/brbi.1996.0025

Ontogeny of the response of human peripheral blood T cells to glucocorticoids

Annemieke Kavelaars, Bernard Cats, Gerard H.A. Visser, Ben J.M. Zegers, Joost M. Bakker, Emmelien P. Van Rees, Cobi J. Heijnen

Symptom Research CAO

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The inhibitory effect of steroids such as dexamethasone on the immune response of adults has been widely documented. Little is known, however, about the effect of these agents on the developing immune system in newborns. The present study describes the ontogeny of the sensitivity of peripheral blood T cells to dexamethasone during the first year of life. Cord blood T cells of preterm or term infants appear to be extremely sensitive to inhibition of the proliferative response. This high sensitivity of cells to dexamethasone can still be observed in the first 2 weeks after birth. Subsequently, the sensitivity to dexamethasone inhibition of T-cell proliferation gradually decreases. At 1 year of age, the adult response pattern has been acquired.

Original language	English (US)
Pages (from-to)	288-297
Number of pages	10
Journal	Brain, behavior, and immunity
Volume	10
Issue number	3
DOIs	https://doi.org/10.1006/brbi.1996.0025
State	Published - Sep 1996

ASJC Scopus subject areas

Immunology
Endocrine and Autonomic Systems
Behavioral Neuroscience

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10.1006/brbi.1996.0025

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title = "Ontogeny of the response of human peripheral blood T cells to glucocorticoids",

abstract = "The inhibitory effect of steroids such as dexamethasone on the immune response of adults has been widely documented. Little is known, however, about the effect of these agents on the developing immune system in newborns. The present study describes the ontogeny of the sensitivity of peripheral blood T cells to dexamethasone during the first year of life. Cord blood T cells of preterm or term infants appear to be extremely sensitive to inhibition of the proliferative response. This high sensitivity of cells to dexamethasone can still be observed in the first 2 weeks after birth. Subsequently, the sensitivity to dexamethasone inhibition of T-cell proliferation gradually decreases. At 1 year of age, the adult response pattern has been acquired.",

author = "Annemieke Kavelaars and Bernard Cats and Visser, {Gerard H.A.} and Zegers, {Ben J.M.} and Bakker, {Joost M.} and {Van Rees}, {Emmelien P.} and Heijnen, {Cobi J.}",

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AU - Kavelaars, Annemieke

AU - Cats, Bernard

AU - Visser, Gerard H.A.

AU - Zegers, Ben J.M.

AU - Bakker, Joost M.

AU - Van Rees, Emmelien P.

AU - Heijnen, Cobi J.

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N2 - The inhibitory effect of steroids such as dexamethasone on the immune response of adults has been widely documented. Little is known, however, about the effect of these agents on the developing immune system in newborns. The present study describes the ontogeny of the sensitivity of peripheral blood T cells to dexamethasone during the first year of life. Cord blood T cells of preterm or term infants appear to be extremely sensitive to inhibition of the proliferative response. This high sensitivity of cells to dexamethasone can still be observed in the first 2 weeks after birth. Subsequently, the sensitivity to dexamethasone inhibition of T-cell proliferation gradually decreases. At 1 year of age, the adult response pattern has been acquired.

AB - The inhibitory effect of steroids such as dexamethasone on the immune response of adults has been widely documented. Little is known, however, about the effect of these agents on the developing immune system in newborns. The present study describes the ontogeny of the sensitivity of peripheral blood T cells to dexamethasone during the first year of life. Cord blood T cells of preterm or term infants appear to be extremely sensitive to inhibition of the proliferative response. This high sensitivity of cells to dexamethasone can still be observed in the first 2 weeks after birth. Subsequently, the sensitivity to dexamethasone inhibition of T-cell proliferation gradually decreases. At 1 year of age, the adult response pattern has been acquired.

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Ontogeny of the response of human peripheral blood T cells to glucocorticoids

Abstract

ASJC Scopus subject areas

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