Abstract
It has recently been demonstrated that various forms of immune modification result in a profound attenuation of the opiate withdrawal syndrome. Herein we investigate the extent to which some of the immune modifiers active in withdrawal attenuation affect other opiate related behaviors, namely antinociception and the development of tolerance to this effect. The observations demonstrate that immune modification by cyclosporine and irradiation exposure result in an alteration of the acute antinociceptive effect of morphine; while none of these treatments modify the development of tolerance to this property of morphine.
Original language | English (US) |
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Pages (from-to) | 401-404 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 385 |
Issue number | 2 |
DOIs | |
State | Published - Oct 22 1986 |
Externally published | Yes |
Keywords
- Antinociception
- Cyclosporine
- Interferon
- Irradiation
- Morphine
- Tolerance
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology