TY - JOUR
T1 - Opioid receptors in psoriatic skin
T2 - Relationship with itch
AU - Kupczyk, Piotr
AU - Reich, Adam
AU - Hołysz, Marcin
AU - Gajda, Mariusz
AU - Wysokińska, Edyta
AU - Kobuszewska, Anna
AU - Nevozhay, Dmitry
AU - Nowakowska, Beata
AU - Strządała, Leon
AU - Jagodziński, Paweł Piotr
AU - Szepietowski, Jacek C.
N1 - Funding Information:
This study was supported financially by a “Preludium” grant from the Polish National Science Center (UMO-2011/01/N/ NZ4/04946): “Gene and protein analysis of OPRM1/MOR and OPRK1/KOR opioid receptors expression and neurobiological marker of nerve terminals PGP 9.5 in skin of patients with psoriasis with and without pruritus.” in 2011 to 2013. D. Nevozhay acknowledges support from programme #1326, of the Ministry of Education and Science, Russian Federation.
Publisher Copyright:
© 2017 Acta Dermato-Venereologica.
PY - 2017
Y1 - 2017
N2 - Psoriasis is an inflammatory immunogenetic skin disease, often accompanied by itch. Opioid receptors are known regulators of itch sensation in the central nervous system. In the brain, μ-opioid receptors may potentiate itch, while activation of κ-opioid receptors may reduce or even alleviate itch; however, the role of opioid receptors in itch perception in the skin is poorly understood. To further elucidate the role of opioid receptors in the neurobiology of psoriatic itch, punch biopsies of non-lesional and lesional skin of patients with psoriasis and healthy controls were studied. Real-time polymerase chain reaction and immunofluorescence microscopy were used to detect opioid receptor genes and protein expression, respectively. The OPRK1/κ-opioid receptor pathway was found to be downregulated in lesional skin of psoriasis, correlating positively with itch sensation. In contrast, the OPRM1/μ-opioid receptor system was uniformly expressed by epidermal keratinocytes in all analysed groups. These findings suggest that imbalance of epidermal opioid receptors may result in disordered neuroepidermal homeostasis in psoriasis, which could potentiate transmission of itch.
AB - Psoriasis is an inflammatory immunogenetic skin disease, often accompanied by itch. Opioid receptors are known regulators of itch sensation in the central nervous system. In the brain, μ-opioid receptors may potentiate itch, while activation of κ-opioid receptors may reduce or even alleviate itch; however, the role of opioid receptors in itch perception in the skin is poorly understood. To further elucidate the role of opioid receptors in the neurobiology of psoriatic itch, punch biopsies of non-lesional and lesional skin of patients with psoriasis and healthy controls were studied. Real-time polymerase chain reaction and immunofluorescence microscopy were used to detect opioid receptor genes and protein expression, respectively. The OPRK1/κ-opioid receptor pathway was found to be downregulated in lesional skin of psoriasis, correlating positively with itch sensation. In contrast, the OPRM1/μ-opioid receptor system was uniformly expressed by epidermal keratinocytes in all analysed groups. These findings suggest that imbalance of epidermal opioid receptors may result in disordered neuroepidermal homeostasis in psoriasis, which could potentiate transmission of itch.
KW - Itch
KW - Keratinocyte
KW - Neuroinflammation
KW - Neuropeptide
KW - Opioid receptor
KW - Psoriasis
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U2 - 10.2340/00015555-2595
DO - 10.2340/00015555-2595
M3 - Article
C2 - 27958613
AN - SCOPUS:85019048972
SN - 0001-5555
VL - 97
SP - 564
EP - 570
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
IS - 5
ER -