TY - JOUR
T1 - Optical Systems for In Vivo Molecular Imaging of Cancer
AU - Sokolov, Konstantin
AU - Aaron, Jesse
AU - Hsu, Betsy
AU - Nida, Dawn
AU - Gillenwater, Ann
AU - Follen, Michele
AU - MacAulay, Calum
AU - Adler-Storthz, Karen
AU - Korgel, Brian
AU - Descour, Michael
AU - Pasqualini, Renata
AU - Arap, Wadih
AU - Lam, Wan
AU - Richards-Kortum, Rebecca
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2003/12
Y1 - 2003/12
N2 - Progress toward a molecular characterization of cancer would have important clinical benefits; thus, there is an important need to image the molecular features of cancer in vivo. In this paper, we describe a comprehensive strategy to develop inexpensive, rugged and portable optical imaging systems for molecular imaging of cancer, which couples the development of optically active contrast agents with advances in functional genomics of cancer. We describe initial results obtained using optically active contrast agents to image the expression of three well known molecular signatures of neoplasia: including over expression of the epidermal growth factor receptor (EGFR), matrix metallo-proteases (MMPs), and oncoproteins associated with human papillomavirus (HPV) infection. At the same time, we are developing inexpensive, portable optical systems to image the morphologic and molecular signatures of neoplasia noninvasively in real time. These real-time, portable, inexpensive systems can provide tools to characterize the molecular features of cancer in vivo.
AB - Progress toward a molecular characterization of cancer would have important clinical benefits; thus, there is an important need to image the molecular features of cancer in vivo. In this paper, we describe a comprehensive strategy to develop inexpensive, rugged and portable optical imaging systems for molecular imaging of cancer, which couples the development of optically active contrast agents with advances in functional genomics of cancer. We describe initial results obtained using optically active contrast agents to image the expression of three well known molecular signatures of neoplasia: including over expression of the epidermal growth factor receptor (EGFR), matrix metallo-proteases (MMPs), and oncoproteins associated with human papillomavirus (HPV) infection. At the same time, we are developing inexpensive, portable optical systems to image the morphologic and molecular signatures of neoplasia noninvasively in real time. These real-time, portable, inexpensive systems can provide tools to characterize the molecular features of cancer in vivo.
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U2 - 10.1177/153303460300200602
DO - 10.1177/153303460300200602
M3 - Review article
C2 - 14640761
AN - SCOPUS:9144244922
SN - 1533-0346
VL - 2
SP - 491
EP - 504
JO - Technology in Cancer Research and Treatment
JF - Technology in Cancer Research and Treatment
IS - 6
ER -