Oral cancer screening approach based on labeling exfoliated oral cells with molecularly-targeted optical contrast agents

Veronica Leautaud; Charles R. Horres; Vijayashree S. Bhattar; Michelle D. Williams; Ann M. Gillenwater; Rebecca R. Richards-Kortum

doi:10.1117/12.887755

Oral cancer screening approach based on labeling exfoliated oral cells with molecularly-targeted optical contrast agents

Veronica Leautaud, Charles R. Horres, Vijayashree S. Bhattar, Michelle D. Williams, Ann M. Gillenwater, Rebecca R. Richards-Kortum

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Early detection is a potential key to improving the survival rates of oral cancer patients and reducing the morbidity associated with treatment. We seek to improve upon methods of detecting of early malignancies with oral brush biopsies by using immunofluorescence-based assessment of the expression of multiple well-described markers commonly overexpressed in oral cancers, such as Epidermal Growth Factor Receptor (EGFR) and Cytokeratin 8 (CK8). Furthermore, since abnormal cells are often scarce in brush biopsy samples, we seek to use magnetic microparticles targeted to these markers as a means of enriching the concentration of abnormal cells. Finally, we plan to conduct a small pilot study using these methods with brush biopsies from patients of the M. D. Anderson Cancer Center Head and Neck Clinic.

Original language	English (US)
Title of host publication	Photonic Therapeutics and Diagnostics VII
DOIs	https://doi.org/10.1117/12.887755
State	Published - 2011
Event	Photonic Therapeutics and Diagnostics VII - San Francisco, CA, United States Duration: Jan 22 2011 → Jan 24 2011

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7883
ISSN (Print)	1605-7422

Other

Other	Photonic Therapeutics and Diagnostics VII
Country/Territory	United States
City	San Francisco, CA
Period	1/22/11 → 1/24/11

Keywords

Molecular markers
optical contrast agents
oral cancer

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.887755

Cite this

Leautaud, V., Horres, C. R., Bhattar, V. S., Williams, M. D., Gillenwater, A. M., & Richards-Kortum, R. R. (2011). Oral cancer screening approach based on labeling exfoliated oral cells with molecularly-targeted optical contrast agents. In Photonic Therapeutics and Diagnostics VII Article 78832H (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7883). https://doi.org/10.1117/12.887755

Oral cancer screening approach based on labeling exfoliated oral cells with molecularly-targeted optical contrast agents. / Leautaud, Veronica; Horres, Charles R.; Bhattar, Vijayashree S. et al.
Photonic Therapeutics and Diagnostics VII. 2011. 78832H (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7883).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Leautaud, V, Horres, CR, Bhattar, VS, Williams, MD , Gillenwater, AM & Richards-Kortum, RR 2011, Oral cancer screening approach based on labeling exfoliated oral cells with molecularly-targeted optical contrast agents. in Photonic Therapeutics and Diagnostics VII., 78832H, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 7883, Photonic Therapeutics and Diagnostics VII, San Francisco, CA, United States, 1/22/11. https://doi.org/10.1117/12.887755

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abstract = "Early detection is a potential key to improving the survival rates of oral cancer patients and reducing the morbidity associated with treatment. We seek to improve upon methods of detecting of early malignancies with oral brush biopsies by using immunofluorescence-based assessment of the expression of multiple well-described markers commonly overexpressed in oral cancers, such as Epidermal Growth Factor Receptor (EGFR) and Cytokeratin 8 (CK8). Furthermore, since abnormal cells are often scarce in brush biopsy samples, we seek to use magnetic microparticles targeted to these markers as a means of enriching the concentration of abnormal cells. Finally, we plan to conduct a small pilot study using these methods with brush biopsies from patients of the M. D. Anderson Cancer Center Head and Neck Clinic.",

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AU - Gillenwater, Ann M.

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AB - Early detection is a potential key to improving the survival rates of oral cancer patients and reducing the morbidity associated with treatment. We seek to improve upon methods of detecting of early malignancies with oral brush biopsies by using immunofluorescence-based assessment of the expression of multiple well-described markers commonly overexpressed in oral cancers, such as Epidermal Growth Factor Receptor (EGFR) and Cytokeratin 8 (CK8). Furthermore, since abnormal cells are often scarce in brush biopsy samples, we seek to use magnetic microparticles targeted to these markers as a means of enriching the concentration of abnormal cells. Finally, we plan to conduct a small pilot study using these methods with brush biopsies from patients of the M. D. Anderson Cancer Center Head and Neck Clinic.

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Oral cancer screening approach based on labeling exfoliated oral cells with molecularly-targeted optical contrast agents

Abstract

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Keywords

ASJC Scopus subject areas

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