TY - JOUR
T1 - Oral squamous cell carcinoma outcome in adolescent/young adult
T2 - Systematic review and meta-analysis
AU - Kaminagakura, Estela
AU - Tango, Rubens Nisie
AU - Cruz-Perez, Danyel
AU - Bonan, Roberta
AU - Yamamoto de Almeida, Luciana
AU - de Almeida Lança, Maria Letícia
AU - Bonan, Paulo
AU - Martins, Hélder
AU - Takahama, Ademar
AU - Ito, Fábio Augusto
AU - Coutinho-Camillo, Cláudia Malheiros
AU - Lourenço, Silvia Vanessa
AU - Caneppele, Taciana
AU - Sikora, Andrew G.
AU - Kowalski, Luiz Paulo
AU - Young, Simon
N1 - Funding Information:
We thank the Brazilian National Council for Scientific and Technological Development (CNPq) for the research fellowship granted to Estela Kaminagakura (Grant 202408/2019‐1).
Publisher Copyright:
© 2021 Wiley Periodicals LLC.
PY - 2022/2
Y1 - 2022/2
N2 - To perform a systematic review focusing on the prognosis of oral cavity squamous cell carcinoma (OSCC) in young patients (≤40 years old) compared to older (>40 years old). Four databases were used in our search strategy. First, all titles were systematically organized using the Covidence platform online. In the second phase, 118 full texts of potentially eligible studies were analyzed by reviewers independently and in pairs. Twelve studies were considered eligible for data extraction. The relapse was higher in the young than in controls (pooled relative risk (RR) = 1.31; 95% CI [1.10–1.56]). The 5-year disease-free survival (DFS) was worse in young group (pooled hazard ratio (HR) = 0.73; 95% CI [0.63–0.85]) but the 5-year overall survival (OS) estimate was similar between the groups (pooled HR = 0.84; 95% CI [0.70–1.00]). While the 5-year OS was similar between groups, the number of relapses and 5-year DFS were worse in patients with OSCC ≤40 years old.
AB - To perform a systematic review focusing on the prognosis of oral cavity squamous cell carcinoma (OSCC) in young patients (≤40 years old) compared to older (>40 years old). Four databases were used in our search strategy. First, all titles were systematically organized using the Covidence platform online. In the second phase, 118 full texts of potentially eligible studies were analyzed by reviewers independently and in pairs. Twelve studies were considered eligible for data extraction. The relapse was higher in the young than in controls (pooled relative risk (RR) = 1.31; 95% CI [1.10–1.56]). The 5-year disease-free survival (DFS) was worse in young group (pooled hazard ratio (HR) = 0.73; 95% CI [0.63–0.85]) but the 5-year overall survival (OS) estimate was similar between the groups (pooled HR = 0.84; 95% CI [0.70–1.00]). While the 5-year OS was similar between groups, the number of relapses and 5-year DFS were worse in patients with OSCC ≤40 years old.
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U2 - 10.1002/hed.26940
DO - 10.1002/hed.26940
M3 - Review article
C2 - 34808012
AN - SCOPUS:85119605607
SN - 1043-3074
VL - 44
SP - 548
EP - 561
JO - Head and Neck
JF - Head and Neck
IS - 2
ER -