Oral topical cidofovir: Novel route of drug delivery in a severely immunosuppressed patient with refractory multidrug-resistant herpes simplex virus infection

C. R. Sims; K. Thompson; R. F. Chemaly; E. J. Shpall; R. E. Champlin; A. Safdar

doi:10.1111/j.1399-3062.2007.00261.x

Oral topical cidofovir: Novel route of drug delivery in a severely immunosuppressed patient with refractory multidrug-resistant herpes simplex virus infection

C. R. Sims, K. Thompson, R. F. Chemaly, E. J. Shpall, R. E. Champlin, A. Safdar

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We present a case of serious treatment-refractory acyclovir- and foscarnet-resistant herpes simplex virus (HSV) type-1 orolingual infection that responded to oral cidofovir rinses after failure of acyclovir and foscarnet therapy. The use of 3% cidofovir in a saline rinse for refractory mucosal HSV infection appears promising but needs prospective evaluation.

Original language	English (US)
Pages (from-to)	256-259
Number of pages	4
Journal	Transplant Infectious Disease
Volume	9
Issue number	3
DOIs	https://doi.org/10.1111/j.1399-3062.2007.00261.x
State	Published - Sep 2007

Keywords

Cidofovir
Herpes simplex virus
Immunosuppressed
Multidrug resistant
Oral delivery

ASJC Scopus subject areas

Infectious Diseases
Transplantation

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10.1111/j.1399-3062.2007.00261.x

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title = "Oral topical cidofovir: Novel route of drug delivery in a severely immunosuppressed patient with refractory multidrug-resistant herpes simplex virus infection",

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AU - Shpall, E. J.

AU - Champlin, R. E.

AU - Safdar, A.

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AB - We present a case of serious treatment-refractory acyclovir- and foscarnet-resistant herpes simplex virus (HSV) type-1 orolingual infection that responded to oral cidofovir rinses after failure of acyclovir and foscarnet therapy. The use of 3% cidofovir in a saline rinse for refractory mucosal HSV infection appears promising but needs prospective evaluation.

KW - Cidofovir

KW - Herpes simplex virus

KW - Immunosuppressed

KW - Multidrug resistant

KW - Oral delivery

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Oral topical cidofovir: Novel route of drug delivery in a severely immunosuppressed patient with refractory multidrug-resistant herpes simplex virus infection

Abstract

Keywords

ASJC Scopus subject areas

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