Orbital carcinomas treated with adjuvant intensity-modulated radiation therapy

Randa Tao; Dominic Ma; Vinita Takiar; Steven J. Frank; Clifton D. Fuller; G. Brandon Gunn; Beth Michelle Beadle; William H. Morrison; David I. Rosenthal; Mark A. Edson; Bita Esmaeli; Michael E. Kupferman; Ehab Y. Hanna; Adam S. Garden; Jack Phan

doi:10.1002/hed.24044

Orbital carcinomas treated with adjuvant intensity-modulated radiation therapy

Randa Tao, Dominic Ma, Vinita Takiar, Steven J. Frank, Clifton D. Fuller, G. Brandon Gunn, Beth Michelle Beadle, William H. Morrison, David I. Rosenthal, Mark A. Edson, Bita Esmaeli, Michael E. Kupferman, Ehab Y. Hanna, Adam S. Garden, Jack Phan

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background The purpose of this study was to assess outcomes of patients with orbital carcinomas treated with orbital exenteration and intensity-modulated radiation therapy (IMRT). Methods Twenty-nine patients were treated with orbital exenteration and postoperative IMRT between 2002 through 2011; their medical records were retrospectively reviewed. Results Adenoid cystic carcinoma represented the most common histology (41%) followed by squamous cell carcinoma (21%). Perineural invasion (PNI) was identified in 22 patients (76%). The median radiation dose was 60 Gy (range, 60-70). Seven patients (24%) received neck radiation. The median follow-up was 43 months (range, 5-102 months). Five-year local control, overall survival (OS), and disease-free survival rates were 83%, 60%, and 55%, respectively. PNI (p =.01) and especially involvement of a named nerve (p =.001) significantly correlated with worse OS. Conclusion Favorable disease control rates for orbital carcinomas are achievable with IMRT after orbital exenteration even for patients with advanced disease. Toxicity for the contralateral eye was minimal.

Original language	English (US)
Pages (from-to)	E580-E587
Journal	Head and Neck
Volume	38
DOIs	https://doi.org/10.1002/hed.24044
State	Published - Apr 1 2016

Keywords

exenteration
intensity-modulated radiation therapy (IMRT)
orbital carcinomas
patterns of recurrence
preserved eye function

ASJC Scopus subject areas

Otorhinolaryngology

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title = "Orbital carcinomas treated with adjuvant intensity-modulated radiation therapy",

abstract = "Background The purpose of this study was to assess outcomes of patients with orbital carcinomas treated with orbital exenteration and intensity-modulated radiation therapy (IMRT). Methods Twenty-nine patients were treated with orbital exenteration and postoperative IMRT between 2002 through 2011; their medical records were retrospectively reviewed. Results Adenoid cystic carcinoma represented the most common histology (41%) followed by squamous cell carcinoma (21%). Perineural invasion (PNI) was identified in 22 patients (76%). The median radiation dose was 60 Gy (range, 60-70). Seven patients (24%) received neck radiation. The median follow-up was 43 months (range, 5-102 months). Five-year local control, overall survival (OS), and disease-free survival rates were 83%, 60%, and 55%, respectively. PNI (p =.01) and especially involvement of a named nerve (p =.001) significantly correlated with worse OS. Conclusion Favorable disease control rates for orbital carcinomas are achievable with IMRT after orbital exenteration even for patients with advanced disease. Toxicity for the contralateral eye was minimal.",

keywords = "exenteration, intensity-modulated radiation therapy (IMRT), orbital carcinomas, patterns of recurrence, preserved eye function",

author = "Randa Tao and Dominic Ma and Vinita Takiar and Frank, {Steven J.} and Fuller, {Clifton D.} and Gunn, {G. Brandon} and Beadle, {Beth Michelle} and Morrison, {William H.} and Rosenthal, {David I.} and Edson, {Mark A.} and Bita Esmaeli and Kupferman, {Michael E.} and Hanna, {Ehab Y.} and Garden, {Adam S.} and Jack Phan",

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month = apr,

day = "1",

doi = "10.1002/hed.24044",

language = "English (US)",

volume = "38",

pages = "E580--E587",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "Wiley-Liss Inc.",

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TY - JOUR

T1 - Orbital carcinomas treated with adjuvant intensity-modulated radiation therapy

AU - Tao, Randa

AU - Ma, Dominic

AU - Takiar, Vinita

AU - Frank, Steven J.

AU - Fuller, Clifton D.

AU - Gunn, G. Brandon

AU - Beadle, Beth Michelle

AU - Morrison, William H.

AU - Rosenthal, David I.

AU - Edson, Mark A.

AU - Esmaeli, Bita

AU - Kupferman, Michael E.

AU - Hanna, Ehab Y.

AU - Garden, Adam S.

AU - Phan, Jack

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background The purpose of this study was to assess outcomes of patients with orbital carcinomas treated with orbital exenteration and intensity-modulated radiation therapy (IMRT). Methods Twenty-nine patients were treated with orbital exenteration and postoperative IMRT between 2002 through 2011; their medical records were retrospectively reviewed. Results Adenoid cystic carcinoma represented the most common histology (41%) followed by squamous cell carcinoma (21%). Perineural invasion (PNI) was identified in 22 patients (76%). The median radiation dose was 60 Gy (range, 60-70). Seven patients (24%) received neck radiation. The median follow-up was 43 months (range, 5-102 months). Five-year local control, overall survival (OS), and disease-free survival rates were 83%, 60%, and 55%, respectively. PNI (p =.01) and especially involvement of a named nerve (p =.001) significantly correlated with worse OS. Conclusion Favorable disease control rates for orbital carcinomas are achievable with IMRT after orbital exenteration even for patients with advanced disease. Toxicity for the contralateral eye was minimal.

AB - Background The purpose of this study was to assess outcomes of patients with orbital carcinomas treated with orbital exenteration and intensity-modulated radiation therapy (IMRT). Methods Twenty-nine patients were treated with orbital exenteration and postoperative IMRT between 2002 through 2011; their medical records were retrospectively reviewed. Results Adenoid cystic carcinoma represented the most common histology (41%) followed by squamous cell carcinoma (21%). Perineural invasion (PNI) was identified in 22 patients (76%). The median radiation dose was 60 Gy (range, 60-70). Seven patients (24%) received neck radiation. The median follow-up was 43 months (range, 5-102 months). Five-year local control, overall survival (OS), and disease-free survival rates were 83%, 60%, and 55%, respectively. PNI (p =.01) and especially involvement of a named nerve (p =.001) significantly correlated with worse OS. Conclusion Favorable disease control rates for orbital carcinomas are achievable with IMRT after orbital exenteration even for patients with advanced disease. Toxicity for the contralateral eye was minimal.

KW - exenteration

KW - intensity-modulated radiation therapy (IMRT)

KW - orbital carcinomas

KW - patterns of recurrence

KW - preserved eye function

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Orbital carcinomas treated with adjuvant intensity-modulated radiation therapy

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