TY - JOUR
T1 - Osteoarticular Mycoses
AU - the International Consortium for Osteoarticular Mycoses
AU - Gamaletsou, Maria N.
AU - Rammaert, Blandine
AU - Brause, Barry
AU - Bueno, Marimelle A.
AU - Dadwal, Sanjeet S.
AU - Henry, Michael W.
AU - Katragkou, Aspasia
AU - Kontoyiannis, Dimitrios P.
AU - McCarthy, Matthew W.
AU - Miller, Andy O.
AU - Moriyama, Brad
AU - Pana, Zoi Dorothea
AU - Petraitiene, Ruta
AU - Petraitis, Vidmantas
AU - Roilides, Emmanuel
AU - Sarkis, Jean Pierre
AU - Simitsopoulou, Maria
AU - Sipsas, Nikolaos V.
AU - Taj-Aldeen, Saad J.
AU - Zeller, Valérie
AU - Lortholary, Olivier
AU - Walsh, Thomas J.
N1 - Publisher Copyright:
© 2022 American Society for Microbiology. All Rights Reserved.
PY - 2022/12
Y1 - 2022/12
N2 - Osteoarticular mycoses are chronic debilitating infections that require extended courses of antifungal therapy and may warrant expert surgical intervention. As there has been no comprehensive review of these diseases, the International Consortium for Osteoarticular Mycoses prepared a definitive treatise for this important class of infections. Among the etiologies of osteoarticular mycoses are Candida spp., Aspergillus spp., Mucorales, dematiaceous fungi, non-Aspergillus hyaline molds, and endemic mycoses, including those caused by Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides species. This review analyzes the history, epidemiology, pathogenesis, clinical manifestations, diagnostic approaches, inflammatory biomarkers, diagnostic imaging modalities, treatments, and outcomes of osteomyelitis and septic arthritis caused by these organisms. Candida osteomyelitis and Candida arthritis are associated with greater events of hematogenous dissemination than those of most other osteoarticular mycoses. Traumatic inoculation is more commonly associated with osteoarticular mycoses caused by Aspergillus and non-Aspergillus molds. Synovial fluid cultures are highly sensitive in the detection of Candida and Aspergillus arthritis. Relapsed infection, particularly in Candida arthritis, may develop in relation to an inadequate duration of therapy. Overall mortality reflects survival from disseminated infection and underlying host factors.
AB - Osteoarticular mycoses are chronic debilitating infections that require extended courses of antifungal therapy and may warrant expert surgical intervention. As there has been no comprehensive review of these diseases, the International Consortium for Osteoarticular Mycoses prepared a definitive treatise for this important class of infections. Among the etiologies of osteoarticular mycoses are Candida spp., Aspergillus spp., Mucorales, dematiaceous fungi, non-Aspergillus hyaline molds, and endemic mycoses, including those caused by Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides species. This review analyzes the history, epidemiology, pathogenesis, clinical manifestations, diagnostic approaches, inflammatory biomarkers, diagnostic imaging modalities, treatments, and outcomes of osteomyelitis and septic arthritis caused by these organisms. Candida osteomyelitis and Candida arthritis are associated with greater events of hematogenous dissemination than those of most other osteoarticular mycoses. Traumatic inoculation is more commonly associated with osteoarticular mycoses caused by Aspergillus and non-Aspergillus molds. Synovial fluid cultures are highly sensitive in the detection of Candida and Aspergillus arthritis. Relapsed infection, particularly in Candida arthritis, may develop in relation to an inadequate duration of therapy. Overall mortality reflects survival from disseminated infection and underlying host factors.
KW - antifungal therapy
KW - aspergillosis
KW - candidiasis
KW - coccidioidomycosis
KW - cryptococcosis
KW - histoplasmosis
KW - mucormycosis
KW - mycoses
KW - osteomyelitis
KW - phaeohyphomycosis
UR - http://www.scopus.com/inward/record.url?scp=85144591929&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85144591929&partnerID=8YFLogxK
U2 - 10.1128/cmr.00086-19
DO - 10.1128/cmr.00086-19
M3 - Review article
C2 - 36448782
AN - SCOPUS:85144591929
SN - 0893-8512
VL - 35
JO - Clinical Microbiology Reviews
JF - Clinical Microbiology Reviews
IS - 4
ER -