Osteoblasts in prostate cancer metastasis to bone

Christopher J. Logothetis; Sue Hwa Lin

doi:10.1038/nrc1528

Osteoblasts in prostate cancer metastasis to bone

Christopher J. Logothetis, Sue Hwa Lin

Research output: Contribution to journal › Review article › peer-review

471 Scopus citations

Abstract

Metastasis to bone is common in lung, kidney, breast and prostate cancers. However, prostate cancer is unique in that bone is often the only clinically detectable site of metastasis, and the resulting tumours tend to be osteoblastic (bone forming) rather than osteolytic (bone lysing). The interaction between host cells and metastatic cancer cells is an important component of organ-specific cancer progression. How can this knowledge lead to the development of more effective therapies?

Original language	English (US)
Pages (from-to)	21-28
Number of pages	8
Journal	Nature Reviews Cancer
Volume	5
Issue number	1
DOIs	https://doi.org/10.1038/nrc1528
State	Published - Jan 2005

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/nrc1528

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abstract = "Metastasis to bone is common in lung, kidney, breast and prostate cancers. However, prostate cancer is unique in that bone is often the only clinically detectable site of metastasis, and the resulting tumours tend to be osteoblastic (bone forming) rather than osteolytic (bone lysing). The interaction between host cells and metastatic cancer cells is an important component of organ-specific cancer progression. How can this knowledge lead to the development of more effective therapies?",

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Osteoblasts in prostate cancer metastasis to bone

Abstract

ASJC Scopus subject areas

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