@article{47d6f8d3c5fa4f36b783bf0b483cecb7,
title = "Osteolytic paget's bone disease in a young man. Rapid healing with human calcitonin therapy",
abstract = "Paget's bone disease is rare in young adults. Severe osteolytic Paget's bone disease In a 28-year-old man was found to respond, clinically, biochemically, and radiographically, within one month to daily subcutaneous injections of 0.5 mg of synthetic human calcitonin. After two years of therapy, he remains asymptomatic and has no biochemical evidence of Paget's bone disease while receiving Injections three times a week. Despite aggressive disease, young patients may rapidly demonstrate the same beneficial response to synthetic human calcitonin therapy as has been observed in middle-aged or elderly patients with Paget's bone disease.",
author = "Whyte, {Michael P.} and Daniels, {Ethan H.} and Murphy, {William A.}",
note = "Funding Information: From the Division of Bone and Mineral Metabolism, Department of Medicine, Jewish Hospital of St. Louis, and the Section of Musculoskeletal Radiology, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri. This work was supported in pad by Grant RR-00036 from the General Clinical Research Center Branch, Division of Research Facilities and Resources, National Institutes Health, and by a grant-in-aid from the Shrtners Hospitals for Crippled Children (St. Louis Unit). Requests for reprints should be addressed to Dr. Michael P. Whyte, Division of Bone and Mineral Metabolism, Jewish Hospital of St. Louis, 216 South Kingshighway, St. Louis, Missouri 63110. Manuscript accepted April 11, 1964.",
year = "1985",
month = feb,
doi = "10.1016/0002-9343(85)90444-9",
language = "English (US)",
volume = "78",
pages = "326--332",
journal = "The American journal of medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "2",
}