TY - JOUR
T1 - Osteoradionecrosis in patients with salivary gland malignancies
AU - Tucker, J. Rhet
AU - Xu, Li
AU - Sturgis, Erich M.
AU - Mohamed, Abdallah S.R.
AU - Hofstede, Theresa M.
AU - Chambers, Mark S.
AU - Lai, Stephen Y.
AU - Fuller, Clifton David
AU - Beadle, Beth
AU - Gunn, G. Brandon
AU - Hutcheson, Katherine A.
N1 - Publisher Copyright:
© 2016 Elsevier Ltd. All rights reserved.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Purpose The present study was undertaken to evaluate osteoradionecrosis (ORN) in patients with salivary gland malignancies (SGM) after treatment with radiation therapy. Materials and methods The medical records of 172 patients treated with radiation therapy for SGM during a 12-year period (August 2001 to November 2013) were reviewed. Incidence, time to event, staging and management of ORN were analyzed. Results Of the 172 patients, 7 patients (4%) developed ORN (median latency: 19 months, range: 4-72 months). Of those 7 patients, 4 required major surgery, 1 required hyperbaric oxygen therapy (HBO), one required minor debridement, and one required conservative management. Total prescribed radiation dose varied from 50 Gy (1 case) to 70 Gy (1 case) among those patients who developed ORN, and radiotherapy was delivered postoperatively after osseous resection in 4 of 7 cases. Three of the 7 cases of ORN occurred after traumatic injury to the bone. Of the 7 patients who developed ORN, 3 had SGM of the major glands, 3 had other sites of the oral cavity, and 1 had a sinonasal location. Conclusion While the rate of ORN after radiotherapy for SGM was somewhat lower (4%) than previously published data on patients with squamous cell carcinomas of the head and neck treated with radiation therapy (8-14%), ORN necessitating major surgery remains a clinically significant, possible late effect of radiotherapy in SGM survivors. Location of SGM is very important, with cases that developed ORN disproportionally having primary disease arising in the oral cavity.
AB - Purpose The present study was undertaken to evaluate osteoradionecrosis (ORN) in patients with salivary gland malignancies (SGM) after treatment with radiation therapy. Materials and methods The medical records of 172 patients treated with radiation therapy for SGM during a 12-year period (August 2001 to November 2013) were reviewed. Incidence, time to event, staging and management of ORN were analyzed. Results Of the 172 patients, 7 patients (4%) developed ORN (median latency: 19 months, range: 4-72 months). Of those 7 patients, 4 required major surgery, 1 required hyperbaric oxygen therapy (HBO), one required minor debridement, and one required conservative management. Total prescribed radiation dose varied from 50 Gy (1 case) to 70 Gy (1 case) among those patients who developed ORN, and radiotherapy was delivered postoperatively after osseous resection in 4 of 7 cases. Three of the 7 cases of ORN occurred after traumatic injury to the bone. Of the 7 patients who developed ORN, 3 had SGM of the major glands, 3 had other sites of the oral cavity, and 1 had a sinonasal location. Conclusion While the rate of ORN after radiotherapy for SGM was somewhat lower (4%) than previously published data on patients with squamous cell carcinomas of the head and neck treated with radiation therapy (8-14%), ORN necessitating major surgery remains a clinically significant, possible late effect of radiotherapy in SGM survivors. Location of SGM is very important, with cases that developed ORN disproportionally having primary disease arising in the oral cavity.
KW - Hyperbaric oxygen
KW - Osteoradionecrosis
KW - Radiation therapy
KW - Salivary gland neoplasm
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U2 - 10.1016/j.oraloncology.2016.03.006
DO - 10.1016/j.oraloncology.2016.03.006
M3 - Article
C2 - 27208837
AN - SCOPUS:84962016902
SN - 1368-8375
VL - 57
SP - 1
EP - 5
JO - Oral Oncology
JF - Oral Oncology
ER -