Osteosclerosis, osteomalacia, and bone marrow aplasia: A combined late complication of thorotrast administration

William A. Murphy; Paul A. Seligman; Thomas Tillack; John O. Eichling; Steven L. Teitelbaum; J. Heinrich Joist

doi:10.1007/BF00360942

Osteosclerosis, osteomalacia, and bone marrow aplasia: A combined late complication of thorotrast administration

William A. Murphy, Paul A. Seligman, Thomas Tillack, John O. Eichling, Steven L. Teitelbaum, J. Heinrich Joist

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1 Scopus citations

Abstract

A 37-year-old female with thrombocytopenia since childhood developed diffuse osteosclerosis followed by bone marrow aplasia 23 years after Thorotrast administration. Tissue deposition of Thorotrast was documented by radiospectroscopy (liver, bone) and autoradiography (bone). Bone marrow failure in this patient was clinically ascribed to diffuse myelofibrosis, but at autopsy marrow fibrosis was only focal. An unsuspected bone mineralization defect was manifested by thick osteoid seams. It is suggested that osteosclerosis, osteomalacia, and bone marrow aplasia represent a combined experession of Thorotrast cytotoxicity.

Original language	English (US)
Pages (from-to)	234-238
Number of pages	5
Journal	Skeletal radiology
Volume	3
Issue number	4
DOIs	https://doi.org/10.1007/BF00360942
State	Published - Jan 1979
Externally published	Yes

Keywords

Aplasia, bone marrow
Osteomalacia
Osteosclerosis
Radiation, effect of
Thorotrast

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1007/BF00360942

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title = "Osteosclerosis, osteomalacia, and bone marrow aplasia: A combined late complication of thorotrast administration",

abstract = "A 37-year-old female with thrombocytopenia since childhood developed diffuse osteosclerosis followed by bone marrow aplasia 23 years after Thorotrast administration. Tissue deposition of Thorotrast was documented by radiospectroscopy (liver, bone) and autoradiography (bone). Bone marrow failure in this patient was clinically ascribed to diffuse myelofibrosis, but at autopsy marrow fibrosis was only focal. An unsuspected bone mineralization defect was manifested by thick osteoid seams. It is suggested that osteosclerosis, osteomalacia, and bone marrow aplasia represent a combined experession of Thorotrast cytotoxicity.",

keywords = "Aplasia, bone marrow, Osteomalacia, Osteosclerosis, Radiation, effect of, Thorotrast",

author = "Murphy, {William A.} and Seligman, {Paul A.} and Thomas Tillack and Eichling, {John O.} and Teitelbaum, {Steven L.} and {Heinrich Joist}, J.",

year = "1979",

month = jan,

doi = "10.1007/BF00360942",

language = "English (US)",

volume = "3",

pages = "234--238",

journal = "Skeletal radiology",

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TY - JOUR

T1 - Osteosclerosis, osteomalacia, and bone marrow aplasia

T2 - A combined late complication of thorotrast administration

AU - Murphy, William A.

AU - Seligman, Paul A.

AU - Tillack, Thomas

AU - Eichling, John O.

AU - Teitelbaum, Steven L.

AU - Heinrich Joist, J.

PY - 1979/1

Y1 - 1979/1

N2 - A 37-year-old female with thrombocytopenia since childhood developed diffuse osteosclerosis followed by bone marrow aplasia 23 years after Thorotrast administration. Tissue deposition of Thorotrast was documented by radiospectroscopy (liver, bone) and autoradiography (bone). Bone marrow failure in this patient was clinically ascribed to diffuse myelofibrosis, but at autopsy marrow fibrosis was only focal. An unsuspected bone mineralization defect was manifested by thick osteoid seams. It is suggested that osteosclerosis, osteomalacia, and bone marrow aplasia represent a combined experession of Thorotrast cytotoxicity.

AB - A 37-year-old female with thrombocytopenia since childhood developed diffuse osteosclerosis followed by bone marrow aplasia 23 years after Thorotrast administration. Tissue deposition of Thorotrast was documented by radiospectroscopy (liver, bone) and autoradiography (bone). Bone marrow failure in this patient was clinically ascribed to diffuse myelofibrosis, but at autopsy marrow fibrosis was only focal. An unsuspected bone mineralization defect was manifested by thick osteoid seams. It is suggested that osteosclerosis, osteomalacia, and bone marrow aplasia represent a combined experession of Thorotrast cytotoxicity.

KW - Aplasia, bone marrow

KW - Osteomalacia

KW - Osteosclerosis

KW - Radiation, effect of

KW - Thorotrast

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Osteosclerosis, osteomalacia, and bone marrow aplasia: A combined late complication of thorotrast administration

Abstract

Keywords

ASJC Scopus subject areas

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