Abstract
We retrospectively evaluated the outcome of 94 consecutive elderly patients treated at our center for an aggressive lymphoma without a low-grade component. Median survival was 26 months and 5-year overall survival was 39% (27-50%). We then evaluated the outcome of patients refractory to or relapsing after CHOP or CHOP-like chemotherapy. Twenty patients were refractory to first-line therapy and only 1/20 is alive with active lymphoma. Eight patients achieved a partial response and only 3 maintained the partial response while the other 5 patients died. Only 2 of the 27 patients who relapsed after a first complete remission achieved a second sustained complete remission. This study suggests that conventional-dose second-line chemotherapy yields disappointing results in elderly patients with aggressive lymphomas.
Original language | English (US) |
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Pages (from-to) | 1391-1394 |
Number of pages | 4 |
Journal | Leukemia and Lymphoma |
Volume | 45 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2004 |
Externally published | Yes |
Keywords
- Aggressive non-Hodgkin's lymphoma
- Elderly patients
- Prognosis
- Salvage chemotherapy
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research