Outcomes after definitive treatment for cutaneous angiosarcomas of the face and scalp: Reevaluating the role of surgery and radiation therapy

Alison K. Yoder; Ahsan S. Farooqi; Cort Wernz; Aparna Subramaniam; Vinod Ravi; Ryan Goepfert; Erich M. Sturgis; Devarati Mitra; Andrew J. Bishop; B. Ashleigh Guadagnolo

doi:10.1002/hed.27418

Outcomes after definitive treatment for cutaneous angiosarcomas of the face and scalp: Reevaluating the role of surgery and radiation therapy

Alison K. Yoder, Ahsan S. Farooqi, Cort Wernz, Aparna Subramaniam, Vinod Ravi, Ryan Goepfert, Erich M. Sturgis, Devarati Mitra, Andrew J. Bishop, B. Ashleigh Guadagnolo

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: We investigated outcomes and prognostic factors for patients treated for cutaneous angiosarcoma (CA). Methods: We conducted a retrospective review of patients treated for CA of the face and scalp from 1962 to 2019. All received definitive treatment with surgery, radiation (RT), or a combination (S-XRT). The Kaplan–Meier method was used to estimate outcomes. Multivariable analyses were conducted using the Cox proportional hazards model. Results: For the 143 patients evaluated median follow-up was 33 months. Five-year LC was 51% and worse in patients with tumors >5 cm, multifocal tumors, those treated pre-2000, and with single modality therapy (SMT). These remained associated with worse LC on multivariable analysis. The 5-year disease-specific survival (DSS) for the cohort was 56%. Tumor size >5 cm, non-scalp primary site, treatment pre-2000, and SMT were associated with worse DSS. Conclusion: Large or multifocal tumors are negative prognostic factors in patients with head and neck CA. S-XRT improved outcomes.

Original language	English (US)
Pages (from-to)	1943-1951
Number of pages	9
Journal	Head and Neck
Volume	45
Issue number	8
DOIs	https://doi.org/10.1002/hed.27418
State	Published - Aug 2023

Keywords

angiosarcoma
radiation
surgery

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.27418

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@article{4923cd3a9d784ac9b5ab7fe94f82bf6b,

title = "Outcomes after definitive treatment for cutaneous angiosarcomas of the face and scalp: Reevaluating the role of surgery and radiation therapy",

abstract = "Introduction: We investigated outcomes and prognostic factors for patients treated for cutaneous angiosarcoma (CA). Methods: We conducted a retrospective review of patients treated for CA of the face and scalp from 1962 to 2019. All received definitive treatment with surgery, radiation (RT), or a combination (S-XRT). The Kaplan–Meier method was used to estimate outcomes. Multivariable analyses were conducted using the Cox proportional hazards model. Results: For the 143 patients evaluated median follow-up was 33 months. Five-year LC was 51% and worse in patients with tumors >5 cm, multifocal tumors, those treated pre-2000, and with single modality therapy (SMT). These remained associated with worse LC on multivariable analysis. The 5-year disease-specific survival (DSS) for the cohort was 56%. Tumor size >5 cm, non-scalp primary site, treatment pre-2000, and SMT were associated with worse DSS. Conclusion: Large or multifocal tumors are negative prognostic factors in patients with head and neck CA. S-XRT improved outcomes.",

keywords = "angiosarcoma, radiation, surgery",

author = "Yoder, {Alison K.} and Farooqi, {Ahsan S.} and Cort Wernz and Aparna Subramaniam and Vinod Ravi and Ryan Goepfert and Sturgis, {Erich M.} and Devarati Mitra and Bishop, {Andrew J.} and Guadagnolo, {B. Ashleigh}",

note = "Funding Information: Supported in part by Cancer Center Support (Core) Grant P30 CA016672 from the National Cancer Institute, National Institutes of Health, to The University of Texas MD Anderson Cancer Center. Publisher Copyright: {\textcopyright} 2023 Wiley Periodicals LLC.",

year = "2023",

month = aug,

doi = "10.1002/hed.27418",

language = "English (US)",

volume = "45",

pages = "1943--1951",

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T1 - Outcomes after definitive treatment for cutaneous angiosarcomas of the face and scalp

T2 - Reevaluating the role of surgery and radiation therapy

AU - Yoder, Alison K.

AU - Farooqi, Ahsan S.

AU - Wernz, Cort

AU - Subramaniam, Aparna

AU - Ravi, Vinod

AU - Goepfert, Ryan

AU - Sturgis, Erich M.

AU - Mitra, Devarati

AU - Bishop, Andrew J.

AU - Guadagnolo, B. Ashleigh

N1 - Funding Information: Supported in part by Cancer Center Support (Core) Grant P30 CA016672 from the National Cancer Institute, National Institutes of Health, to The University of Texas MD Anderson Cancer Center. Publisher Copyright: © 2023 Wiley Periodicals LLC.

PY - 2023/8

Y1 - 2023/8

N2 - Introduction: We investigated outcomes and prognostic factors for patients treated for cutaneous angiosarcoma (CA). Methods: We conducted a retrospective review of patients treated for CA of the face and scalp from 1962 to 2019. All received definitive treatment with surgery, radiation (RT), or a combination (S-XRT). The Kaplan–Meier method was used to estimate outcomes. Multivariable analyses were conducted using the Cox proportional hazards model. Results: For the 143 patients evaluated median follow-up was 33 months. Five-year LC was 51% and worse in patients with tumors >5 cm, multifocal tumors, those treated pre-2000, and with single modality therapy (SMT). These remained associated with worse LC on multivariable analysis. The 5-year disease-specific survival (DSS) for the cohort was 56%. Tumor size >5 cm, non-scalp primary site, treatment pre-2000, and SMT were associated with worse DSS. Conclusion: Large or multifocal tumors are negative prognostic factors in patients with head and neck CA. S-XRT improved outcomes.

AB - Introduction: We investigated outcomes and prognostic factors for patients treated for cutaneous angiosarcoma (CA). Methods: We conducted a retrospective review of patients treated for CA of the face and scalp from 1962 to 2019. All received definitive treatment with surgery, radiation (RT), or a combination (S-XRT). The Kaplan–Meier method was used to estimate outcomes. Multivariable analyses were conducted using the Cox proportional hazards model. Results: For the 143 patients evaluated median follow-up was 33 months. Five-year LC was 51% and worse in patients with tumors >5 cm, multifocal tumors, those treated pre-2000, and with single modality therapy (SMT). These remained associated with worse LC on multivariable analysis. The 5-year disease-specific survival (DSS) for the cohort was 56%. Tumor size >5 cm, non-scalp primary site, treatment pre-2000, and SMT were associated with worse DSS. Conclusion: Large or multifocal tumors are negative prognostic factors in patients with head and neck CA. S-XRT improved outcomes.

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Outcomes after definitive treatment for cutaneous angiosarcomas of the face and scalp: Reevaluating the role of surgery and radiation therapy

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