Outcomes after definitive treatment for cutaneous angiosarcomas of the face and scalp: Reevaluating the role of surgery and radiation therapy

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Abstract

Introduction: We investigated outcomes and prognostic factors for patients treated for cutaneous angiosarcoma (CA). Methods: We conducted a retrospective review of patients treated for CA of the face and scalp from 1962 to 2019. All received definitive treatment with surgery, radiation (RT), or a combination (S-XRT). The Kaplan–Meier method was used to estimate outcomes. Multivariable analyses were conducted using the Cox proportional hazards model. Results: For the 143 patients evaluated median follow-up was 33 months. Five-year LC was 51% and worse in patients with tumors >5 cm, multifocal tumors, those treated pre-2000, and with single modality therapy (SMT). These remained associated with worse LC on multivariable analysis. The 5-year disease-specific survival (DSS) for the cohort was 56%. Tumor size >5 cm, non-scalp primary site, treatment pre-2000, and SMT were associated with worse DSS. Conclusion: Large or multifocal tumors are negative prognostic factors in patients with head and neck CA. S-XRT improved outcomes.

Original languageEnglish (US)
Pages (from-to)1943-1951
Number of pages9
JournalHead and Neck
Volume45
Issue number8
DOIs
StatePublished - Aug 2023

Keywords

  • angiosarcoma
  • radiation
  • surgery

ASJC Scopus subject areas

  • Otorhinolaryngology

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