Outcomes after radiation therapy for T2N0/stage II glottic squamous cell carcinoma

Karine A. Al Feghali; Bassem Y. Youssef; Abdallah S.R. Mohamed; Lara Hilal; Blaine D. Smith; Ibrahim Abu-Gheida; Georges Farha; G. Brandon Gunn; Jack Phan; Jan Lewin; Apurva Thekdi; William H. Morrison; Adam S. Garden; Clifton David Fuller; David I. Rosenthal

doi:10.1002/hed.26308

Outcomes after radiation therapy for T2N0/stage II glottic squamous cell carcinoma

Karine A. Al Feghali, Bassem Y. Youssef, Abdallah S.R. Mohamed, Lara Hilal, Blaine D. Smith, Ibrahim Abu-Gheida, Georges Farha, G. Brandon Gunn, Jack Phan, Jan Lewin, Apurva Thekdi, William H. Morrison, Adam S. Garden, Clifton David Fuller, David I. Rosenthal

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11 Scopus citations

Abstract

Background: We report outcomes for patients with T2N0M0 glottic squamous cell carcinoma (SCC) treated with radiation therapy (RT). Methods: Patients who received definitive RT for T2 glottic SCC from 2000 through 2013 were retrospectively reviewed. Results: One hundred and thirteen patients were analyzed (median follow-up time 91 months; 85 patients received three-dimensional conformal radiotherapy [3D-CRT] and 28 received intensity-modulated radiation therapy [IMRT]). Fractionation was conventional (58%) or altered (42%); 20 patients (18%) received concurrent chemotherapy. Five-year local control was 83% for the 3D-CRT vs 81% for the IMRT group (P =.76). The ultimate locoregional control at 5 years was 100% for IMRT vs 91% for 3D-CRT (P =.1). The 5-year overall survival (OS) was 78% for 3D-CRT vs 81% for IMRT (P =.83). On multivariate analysis, younger age was the only independent predictor of improved OS (P =.0002). Conclusions: Oncologic and survival outcomes were excellent for patients with T2N0 glottic cancer. Patients treated with IMRT and 3D-CRT had no statistically significant differences in all investigated endpoints.

Original language	English (US)
Pages (from-to)	2791-2800
Number of pages	10
Journal	Head and Neck
Volume	42
Issue number	10
DOIs	https://doi.org/10.1002/hed.26308
State	Published - Oct 1 2020

Keywords

T2
larynx
outcomes
radiotherapy
survival

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.26308

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Al Feghali, K. A., Youssef, B. Y., Mohamed, A. S. R., Hilal, L., Smith, B. D., Abu-Gheida, I., Farha, G., Gunn, G. B., Phan, J., Lewin, J., Thekdi, A., Morrison, W. H., Garden, A. S., Fuller, C. D., & Rosenthal, D. I. (2020). Outcomes after radiation therapy for T2N0/stage II glottic squamous cell carcinoma. Head and Neck, 42(10), 2791-2800. https://doi.org/10.1002/hed.26308

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title = "Outcomes after radiation therapy for T2N0/stage II glottic squamous cell carcinoma",

abstract = "Background: We report outcomes for patients with T2N0M0 glottic squamous cell carcinoma (SCC) treated with radiation therapy (RT). Methods: Patients who received definitive RT for T2 glottic SCC from 2000 through 2013 were retrospectively reviewed. Results: One hundred and thirteen patients were analyzed (median follow-up time 91 months; 85 patients received three-dimensional conformal radiotherapy [3D-CRT] and 28 received intensity-modulated radiation therapy [IMRT]). Fractionation was conventional (58%) or altered (42%); 20 patients (18%) received concurrent chemotherapy. Five-year local control was 83% for the 3D-CRT vs 81% for the IMRT group (P =.76). The ultimate locoregional control at 5 years was 100% for IMRT vs 91% for 3D-CRT (P =.1). The 5-year overall survival (OS) was 78% for 3D-CRT vs 81% for IMRT (P =.83). On multivariate analysis, younger age was the only independent predictor of improved OS (P =.0002). Conclusions: Oncologic and survival outcomes were excellent for patients with T2N0 glottic cancer. Patients treated with IMRT and 3D-CRT had no statistically significant differences in all investigated endpoints.",

keywords = "T2, larynx, outcomes, radiotherapy, survival",

author = "{Al Feghali}, {Karine A.} and Youssef, {Bassem Y.} and Mohamed, {Abdallah S.R.} and Lara Hilal and Smith, {Blaine D.} and Ibrahim Abu-Gheida and Georges Farha and Gunn, {G. Brandon} and Jack Phan and Jan Lewin and Apurva Thekdi and Morrison, {William H.} and Garden, {Adam S.} and Fuller, {Clifton David} and Rosenthal, {David I.}",

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doi = "10.1002/hed.26308",

language = "English (US)",

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T1 - Outcomes after radiation therapy for T2N0/stage II glottic squamous cell carcinoma

AU - Al Feghali, Karine A.

AU - Youssef, Bassem Y.

AU - Mohamed, Abdallah S.R.

AU - Hilal, Lara

AU - Smith, Blaine D.

AU - Abu-Gheida, Ibrahim

AU - Farha, Georges

AU - Gunn, G. Brandon

AU - Phan, Jack

AU - Lewin, Jan

AU - Thekdi, Apurva

AU - Morrison, William H.

AU - Garden, Adam S.

AU - Fuller, Clifton David

AU - Rosenthal, David I.

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Background: We report outcomes for patients with T2N0M0 glottic squamous cell carcinoma (SCC) treated with radiation therapy (RT). Methods: Patients who received definitive RT for T2 glottic SCC from 2000 through 2013 were retrospectively reviewed. Results: One hundred and thirteen patients were analyzed (median follow-up time 91 months; 85 patients received three-dimensional conformal radiotherapy [3D-CRT] and 28 received intensity-modulated radiation therapy [IMRT]). Fractionation was conventional (58%) or altered (42%); 20 patients (18%) received concurrent chemotherapy. Five-year local control was 83% for the 3D-CRT vs 81% for the IMRT group (P =.76). The ultimate locoregional control at 5 years was 100% for IMRT vs 91% for 3D-CRT (P =.1). The 5-year overall survival (OS) was 78% for 3D-CRT vs 81% for IMRT (P =.83). On multivariate analysis, younger age was the only independent predictor of improved OS (P =.0002). Conclusions: Oncologic and survival outcomes were excellent for patients with T2N0 glottic cancer. Patients treated with IMRT and 3D-CRT had no statistically significant differences in all investigated endpoints.

AB - Background: We report outcomes for patients with T2N0M0 glottic squamous cell carcinoma (SCC) treated with radiation therapy (RT). Methods: Patients who received definitive RT for T2 glottic SCC from 2000 through 2013 were retrospectively reviewed. Results: One hundred and thirteen patients were analyzed (median follow-up time 91 months; 85 patients received three-dimensional conformal radiotherapy [3D-CRT] and 28 received intensity-modulated radiation therapy [IMRT]). Fractionation was conventional (58%) or altered (42%); 20 patients (18%) received concurrent chemotherapy. Five-year local control was 83% for the 3D-CRT vs 81% for the IMRT group (P =.76). The ultimate locoregional control at 5 years was 100% for IMRT vs 91% for 3D-CRT (P =.1). The 5-year overall survival (OS) was 78% for 3D-CRT vs 81% for IMRT (P =.83). On multivariate analysis, younger age was the only independent predictor of improved OS (P =.0002). Conclusions: Oncologic and survival outcomes were excellent for patients with T2N0 glottic cancer. Patients treated with IMRT and 3D-CRT had no statistically significant differences in all investigated endpoints.

KW - T2

KW - larynx

KW - outcomes

KW - radiotherapy

KW - survival

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JO - Head and Neck

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IS - 10

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Outcomes after radiation therapy for T2N0/stage II glottic squamous cell carcinoma

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