TY - JOUR
T1 - Outpatient antibiotic treatment in low-risk febrile neutropenic cancer patients
AU - Escalante, Carmen P.
AU - Rubenstein, Edward B.
AU - Rolston, Kenneth V.I.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1996/9
Y1 - 1996/9
N2 - Traditionally febrile neutropenic patients have been treated with parenteral antibiotics in an inpatient setting; however, recent work by several investigators has demonstrated successful treatment with both parenteral and oral antibiotics in an ambulatory environment. This has been accomplished by identification of low-risk neutropenic patients, advances in broad-spectrum antibiotics with long half-lives and stabilities, the introduction of the oral quinolones, home health-care initiatives, improvements in vascular access devices, and development of technically enhanced antibiotic delivery systems. Outpatient antibiotic therapy for febrile episodes in low-risk neutropenic patients should now be considered an acceptable alternative to hospital-based treatment. This review focuses on the development and rationale of risk stratification and examines the results of various outpatient antibiotic trials recently completed.
AB - Traditionally febrile neutropenic patients have been treated with parenteral antibiotics in an inpatient setting; however, recent work by several investigators has demonstrated successful treatment with both parenteral and oral antibiotics in an ambulatory environment. This has been accomplished by identification of low-risk neutropenic patients, advances in broad-spectrum antibiotics with long half-lives and stabilities, the introduction of the oral quinolones, home health-care initiatives, improvements in vascular access devices, and development of technically enhanced antibiotic delivery systems. Outpatient antibiotic therapy for febrile episodes in low-risk neutropenic patients should now be considered an acceptable alternative to hospital-based treatment. This review focuses on the development and rationale of risk stratification and examines the results of various outpatient antibiotic trials recently completed.
KW - Neutropenic fever
KW - Outpatient antibiotics
KW - Risk stratification
UR - http://www.scopus.com/inward/record.url?scp=0030225708&partnerID=8YFLogxK
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U2 - 10.1007/BF01788842
DO - 10.1007/BF01788842
M3 - Article
C2 - 8883229
AN - SCOPUS:0030225708
SN - 0941-4355
VL - 4
SP - 358
EP - 363
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 5
ER -