TY - JOUR
T1 - Ovarian involvement by serous surface papillary carcinoma
AU - Mulhollan, Thomas J.
AU - Silva, Elvio G.
AU - Tornos, Carmen
AU - Guerrieri, Claudio
AU - Fromm, Geri Lynn
AU - Gershenson, David
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1994/4
Y1 - 1994/4
N2 - Serous surface papillary carcinoma (SSPC) is a multicentric peritoneal tumor that can spare or minimally involve the ovaries and has been reported to be more aggressive than the usual form of serous carcinoma of the ovary (SCO). From 360 serous ovarian carcinomas, we selected 87 cases with high histological grade, clinical stage III, residual disease after the first operation, similar chemotherapeutic regimens, and at least a 4-year follow-up period. Of these, 33 patients had SSPC in which the tumors were smaller than 10 mm (ovaries not enlarged), and 54 had SCO in which the tumors were larger than 5.0 cm. The 33 cases with SSPC were then subdivided according to tumor size: (a) 17 patients had SSPC characterized by tumors that were smaller than 5.0 mm in largest dimension and that involved only the ovarian surface or showed minimal superficial invasion of the ovarian cortex (maximum depth, 3 mm); (b) 16 patients had SSPC characterized by tumors that measured 5.1 to 10 mm and involved the ovarian surface, cortex, and/or medulla. The subdivision of the SSPC into small and large types was found to be of no clinical statistical significance; thus, the two groups were recombined as a single group. The difference in length of survival between SSPC and SCO at 24 months (39% versus 32%, respectively) and the median survival times (SSPC = 17 months and SCO = 18 months) were not statistically significant. However, the 48- month survival rate (SSPC = 28% and SCO = 9%), was statistically significant (p = 0.027). The SSPC group had a better long-term prognosis than did the SCO group. Both groups had a similar median survival time.
AB - Serous surface papillary carcinoma (SSPC) is a multicentric peritoneal tumor that can spare or minimally involve the ovaries and has been reported to be more aggressive than the usual form of serous carcinoma of the ovary (SCO). From 360 serous ovarian carcinomas, we selected 87 cases with high histological grade, clinical stage III, residual disease after the first operation, similar chemotherapeutic regimens, and at least a 4-year follow-up period. Of these, 33 patients had SSPC in which the tumors were smaller than 10 mm (ovaries not enlarged), and 54 had SCO in which the tumors were larger than 5.0 cm. The 33 cases with SSPC were then subdivided according to tumor size: (a) 17 patients had SSPC characterized by tumors that were smaller than 5.0 mm in largest dimension and that involved only the ovarian surface or showed minimal superficial invasion of the ovarian cortex (maximum depth, 3 mm); (b) 16 patients had SSPC characterized by tumors that measured 5.1 to 10 mm and involved the ovarian surface, cortex, and/or medulla. The subdivision of the SSPC into small and large types was found to be of no clinical statistical significance; thus, the two groups were recombined as a single group. The difference in length of survival between SSPC and SCO at 24 months (39% versus 32%, respectively) and the median survival times (SSPC = 17 months and SCO = 18 months) were not statistically significant. However, the 48- month survival rate (SSPC = 28% and SCO = 9%), was statistically significant (p = 0.027). The SSPC group had a better long-term prognosis than did the SCO group. Both groups had a similar median survival time.
KW - Histological grade
KW - Ovary
KW - Peritoneal tumor
KW - Serous carcinoma of the ovary
KW - Serous surface papillary carcinoma
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U2 - 10.1097/00004347-199404000-00003
DO - 10.1097/00004347-199404000-00003
M3 - Article
C2 - 8005732
AN - SCOPUS:0028281235
SN - 0277-1691
VL - 13
SP - 120
EP - 126
JO - International Journal of Gynecological Pathology
JF - International Journal of Gynecological Pathology
IS - 2
ER -